Granzyme B as a prognostic marker of cervical intraepithelial neoplasia

Granzyme B as a prognostic marker of cervical intraepithelial neoplasia

Author Kondo, Maika Crisianne Autor UNIFESP Google Scholar
Ribalta, Julisa Chamorro Lascasas Autor UNIFESP Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Alves, Maria Teresa de Seixas Autor UNIFESP Google Scholar
Focchi, Gustavo Rubino de Azevedo Autor UNIFESP Google Scholar
Martins, Nelson Valente Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Granzyme B (GrB) is a serine protease synthesized in T lympocytes (CTL), released after T-cell activation resulting from exogenous stimulation. With perforin, GrB discharges apoptotic signals to a target cell and therefore constitutes a marker to identify activated CTL. We aimed to quantify GrB expression by immunohistochemistry staining in 12 tissue fragments of cervical carcinoma, 33 cervical intraepithelial neoplasias treated by LLTEZ and nine cervical pieces without disease. Activated cytotoxic lymphocyte mean values (20 HPF-400x) in both epithelial and stromal pars were 7.11 cells in tissue without neoplasia, 33.45 cells in cervical intraepithelial neoplasia and 139.75 cells in carcinoma samples, with a statistical difference between them. Comparative analysis in the CIN group showed an expressive difference between cases with disease recurrence (19.28 cells) and without recurrence (37.26 cells). Thus, the relation between number of activated CTLs found at the moment of treatment and clinical evolution determined in this study, suggest GrB use as a prognostic marker.
Keywords granzyme B
cervical intraepithelial neoplasia
prognostic marker
immunologic marker
Language English
Date 2005-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 26, n. 1, p. 87-89, 2005.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 87-89
Access rights Closed access
Type Article
Web of Science ID WOS:000227340800017

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