Low-dose 5-fluorouracil adjuvant in laser therapy for HPV lesions in immunosuppressed patients and cases of difficult control

Low-dose 5-fluorouracil adjuvant in laser therapy for HPV lesions in immunosuppressed patients and cases of difficult control

Author Speck, Neila Maria de Góis Autor UNIFESP Google Scholar
Ribalta, Julisa Chamorro Lascasas Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Costa, RRL Google Scholar
Kesselring, F. Autor UNIFESP Google Scholar
Freitas, V. G. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hosp AC Camargo Fund Antonio Prudente
Abstract The authors established a protocol for the use of 5-fluorouracil (5FU) adjuvant in lasertherapy for clinical and subclinical HPV infection in immunosuppressed patients, persistent lesions and as reinforcement treatment in cases of poor progress. Sixty-four patients were evaluated, of whom 26 were immunosuppressed, 34 presented persistent lesions and four received intravaginal reinforcement treatment with 2.5 g 5% 5FU every two weeks, or biweekly vulvar reinforcement after lasertherapy. On average, five 5FU courses were used, but in the immunossuppressed patients its use was maintained indefinitely. The rate of complete response was 66%, but the immunossuppressed patients showed less response (46.2%) when compared with the persistent lesion/reinforcement treatment group (78.9%). The responses were positive in the two groups when compared to that with no response. We deem the use of low-dose 5FU an excellent alternative in cases of difficult HPV progress, presenting a low cost and minimal side-effects.
Keywords 5-fluorouracil
HPV
Language English
Date 2004-01-01
Published in European Journal Of Gynaecological Oncology. Montreal: I R O G Canada, Inc, v. 25, n. 5, p. 597-599, 2004.
ISSN 0392-2936 (Sherpa/Romeo, impact factor)
Publisher I R O G Canada, Inc
Extent 597-599
Origin http://www.irog.net/download/?magazine=87
Access rights Closed access
Type Article
Web of Science ID WOS:000224169800013
URI http://repositorio.unifesp.br/11600/43590

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account