Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy

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dc.contributor.author Carvalho, R. D.
dc.contributor.author Arida, Ricardo Mario [UNIFESP]
dc.contributor.author Cavalheiro, Esper Abrão [UNIFESP]
dc.date.accessioned 2018-06-15T17:17:30Z
dc.date.available 2018-06-15T17:17:30Z
dc.date.issued 2003-02-01
dc.identifier https://dx.doi.org/10.1046/j.1528-1157.2003.32202.x
dc.identifier.citation Epilepsia. Hoboken: Wiley-blackwell, v. 44, n. 2, p. 165-170, 2003.
dc.identifier.issn 0013-9580
dc.identifier.uri http://repositorio.unifesp.br/11600/43552
dc.description.abstract Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4-5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1-3 and 5 and longer after discharge duration in stages 1-4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species. en
dc.format.extent 165-170
dc.language.iso eng
dc.publisher Wiley-Blackwell
dc.relation.ispartof Epilepsia
dc.rights Acesso aberto
dc.subject kindling en
dc.subject epilepsy en
dc.subject Proechimys en
dc.subject rats en
dc.title Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy en
dc.type Artigo
dc.rights.license http://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ Fed Sao Paulo, Lab Neurol Expt, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Lab Neurol Expt, Escola Paulista Med, BR-04023900 Sao Paulo, Brazil
dc.identifier.doi 10.1046/j.1528-1157.2003.32202.x
dc.description.source Web of Science
dc.identifier.wos WOS:000180917100005



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