Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy

Amygdala kindling in Proechimys guyannensis rat: An animal model of resistance to epilepsy

Autor Carvalho, R. D. Google Scholar
Arida, Ricardo Mario Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose: This study examined the effect of amygdala kindling development in Proechimys guayannensis rat, a common rodent of the Amazon basin.Methods: Adult male P. guayannensis animals (n = 43) and adult male Wistar rats (n = 14) were submitted to electrical amygdala kindling.Results: From 43 Proechimys rats submitted to the kindling process, only three animals reached stage 5 of kindling. During the kindling development (stages 4-5), these animals had behavioral alterations different from those observed in Wistar rats. A longer time spent in stages 1-3 and 5 and longer after discharge duration in stages 1-4 was observed in the Proechimys group compared with the Wistar group. The number of wet-dog shakes also was reduced in the Proechimys group during the kindling process.Conclusions: These findings suggest natural endogenous inhibitory mechanisms in this animal species.
Assunto kindling
epilepsy
Proechimys
rats
Idioma Inglês
Data 2003-02-01
Publicado em Epilepsia. Hoboken: Wiley-blackwell, v. 44, n. 2, p. 165-170, 2003.
ISSN 0013-9580 (Sherpa/Romeo, fator de impacto)
Editor Wiley-Blackwell
Extensão 165-170
Fonte https://dx.doi.org/10.1046/j.1528-1157.2003.32202.x
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000180917100005
URI http://repositorio.unifesp.br/11600/43552

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