Reciprocal Cdc25A and p27 expression in B-cell non-Hodgkin lymphomas

Reciprocal Cdc25A and p27 expression in B-cell non-Hodgkin lymphomas

Author Junior, G. M. Google Scholar
Colleoni, Gisele Wally Braga Autor UNIFESP Google Scholar
Cangi, M. G. Google Scholar
Murphy, M. Google Scholar
Sherburne, B. Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Loda, M. Google Scholar
Institution Harvard Univ
Brigham & Womens Hosp
Universidade Federal de São Paulo (UNIFESP)
Abstract Cell cycle regulation is often altered in cancer and deregulation of the cell cycle checkpoints is common in human neoplasia. The dual-specificity phosphatase Cdc25A and the cell cycle inhibitor p27 both play an important role in the regulation of the G1-S transition. We evaluated Cdc25A mRNA expression by in situ hybridization and p27 protein expression by immunohistochemistry in 42 histologically indolent B-cell non-Hodgkin lymphoma (NHLand 51 histologically aggressive B-cell NHL. Overexpression of Cdc25A (>50% tumor cells positive) was detected in 5 of 42 cases (12%) of histologically indolent B-cell NHL and in 29 of 51 (57%) of histologically aggressive B-cell NHL (P < 0.001). In contrast, high p27 protein expression (>50% tumor cells positive) was observed in 29 (69%) cases of indolent but in only one case (2%) of aggressive B-cell NHL (P < 0.0001). Thus, overexpression of Cdc25A and concomitant loss of p27 expression are associated with high grade B-cell NHL and may contribute to their aggressive biologic behavior.
Keywords Cdc25A
non-Hodgkin lymphoma
Language English
Date 2003-09-01
Published in Diagnostic Molecular Pathology. Philadelphia: Lippincott Williams & Wilkins, v. 12, n. 3, p. 128-132, 2003.
ISSN 1052-9551 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 128-132
Access rights Closed access
Type Article
Web of Science ID WOS:000185019500003

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