Dietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brain

Dietary riboflavin restriction and chronic hemin administration does not alter brain function in rats: The importance of vitamin homeostasis in the brain

Author DalPai, Janise Autor UNIFESP Google Scholar
Borges, Andrea Aurélio Autor UNIFESP Google Scholar
Grassl, Christian Autor UNIFESP Google Scholar
Favero Filho, Luiz Antonio Autor UNIFESP Google Scholar
Xavier, Gilberto Fernando Autor UNIFESP Google Scholar
Junqueira, Virginia Berlanga Campos Autor UNIFESP Google Scholar
Lopes, Antonio Carlos Autor UNIFESP Google Scholar
Coimbra, Cicero Galli Autor UNIFESP Google Scholar
Sinigaglia-Coimbra, Rita Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Vitamin B2 deficiency associated with normal dietary intake has been reported inpatients with Parkinson disease (PD), suggesting impaired absorption of this micronutrient. Elevated red meat consumption was thought to contribute as a triggering factor, as the catabolism of hemin (a neurotoxic substance) requires vitamin B2 (Coimbra &Junqueira, 2003). This study tested this hypothesis by verifying the effects of dietary riboflavin restriction associated with hemin administration on rat brain. After 8 months of riboflavin restriction, riboflavin deficiency with or without oral administration of hemin (assessed by erythrocyte glutathion ereductase activity) did not impair motor function or spatial learning; neither altered the volume of substantia nigra or brain concentrations of total glutathione. Partial dietary restriction of riboflavin may failed to induce oxidative stress in the rat brain and dopaminergic degeneration in the rat substantia nigra as suggested to occur in humans by Coimbra & Junqueita, (2003), possibly due to an intact mechanism of nutritional privilege that preserves riboflavin content in the normal rat brain during deficiency states. Contrastingly, polymorphic enzymes or receptors involved in the human cellular uptake of ribofiavin may conceivably impair the transport of this micronutrient not only through the intestinal wall and renal tubules, but also in the brain of PD patients, there by annulling the nutritional privilege of the nervous system.
Keywords FAD
glutathione
hemin
Parkinson's disease
riboflavin
substantia nigra
Language English
Date 2007-11-01
Published in Current Topics In Nutraceutical Research. Coppell: New Century Health Publishers, Llc, v. 5, n. 4, p. 149-155, 2007.
ISSN 1540-7535 (Sherpa/Romeo, impact factor)
Publisher New Century Health Publishers, Llc
Extent 149-155
Origin http://ctnr.newcenturyhealthpublishers.com/about/pdf/ctnrv5p149_156.pdf
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000255670800002
URI http://repositorio.unifesp.br/11600/43477

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