Chronic Infusion of Amyloid-beta Peptide and Sustained Attention Altered alpha 7 Nicotinic Receptor Density in the Rat Brain

Chronic Infusion of Amyloid-beta Peptide and Sustained Attention Altered alpha 7 Nicotinic Receptor Density in the Rat Brain

Autor Viel, Tania Araujo Autor UNIFESP Google Scholar
Caetano, Ariadiny Lima Google Scholar
Albuquerque, Marilia Silva Google Scholar
Araujo, Mariana da Silva Autor UNIFESP Google Scholar
Buck, Hudson de Sousa Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Fac Ciencias Med Santa Casa Sao Paulo
Universidade Federal de São Paulo (UNIFESP)
Resumo It is already known that progressive degeneration of cholinergic neurons in brain areas such as the hippocampus and the cortex leads to memory deficits, as observed in Alzheimer's disease. This work verified the effects of the infusion of amyloid-beta (A beta) peptide associated to an attentional rehearsal on the density of alpha 7 nicotinic cholinergic receptor (nAChR) in the brain of male Wistar rats. Animals received intracerebroventricular infusion of A beta or vehicle (control - C) and their attention was stimulated weekly (Stimulated A beta group: S-A beta and Stimulated Control group: SC) or not (Non-Stimulated A beta group: N-SA beta and Non-Stimulated Control group: N-SC), using an active avoidance apparatus. Conditioned avoidance responses (CAR) were registered. Chronic infusion of A beta caused a 37% reduction in CAR for N-SA beta. In S-A beta, this reduction was not observed. At the end, brains were extracted and autoradiography for alpha 7 nAChR was conducted using [I-125]-alpha-bungarotoxin. There was an increase in alpha 7 density in hippocampus, cortex and amygdala of SA beta animals, together with the memory preservation. In recent findings from our lab using mice infused with A beta and the alpha 7 antagonist methyllycaconitine, and stimulated weekly in the same apparatus, it was observed that memory maintenance was abolished. So, the increase in alpha 7 density in brain areas related to memory might be related to a participation of this receptor in the long-lasting change in synaptic plasticity, which is important to improve and maintain memory consolidation.
Assunto Alpha7 nicotinic receptor
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data 2012-12-01
Publicado em Current Alzheimer Research. Sharjah: Bentham Science Publ Ltd, v. 9, n. 10, p. 1210-1220, 2012.
ISSN 1567-2050 (Sherpa/Romeo, fator de impacto)
Editor Bentham Science Publ Ltd
Extensão 1210-1220
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000311730900011

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