Conjunctival Impression Cytology Changes Induced by Oral Isotretinoin

Conjunctival Impression Cytology Changes Induced by Oral Isotretinoin

Author Queiroga, Isabella Bezerra Wanderley de Google Scholar
Vieira, Luiz Antônio Autor UNIFESP Google Scholar
Barros, Jeison de Nadai Autor UNIFESP Google Scholar
Diniz, Margareth de Fatima Formiga Melo Google Scholar
Morais, Liana Clebia Soares Lima de Google Scholar
Institution Univ Fed Paraiba
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To evaluate the bulbar conjunctiva using impression cytology in patients submitted to oral isotretinoin treatment.Methods: A prospective, cohort study was carried out in a referral ophthalmology practice at the Federal University of Paraiba and in the External Eye Disease Laboratory of the Federal University of Sao Paulo. Twenty-eight patients with acne vulgaris were selected. Impression cytology specimens collected from the temporal bulbar conjunctiva and the superior bulbar conjunctiva of both eyes before and after 3 months of oral isotretinoin treatment were assessed. The doses of isotretinoin varied from 0.35 to 0.88 mg . kg(-1) . d(-1).Results: The percentage of patients in whom impression cytology results were normal was significantly lower during oral isotretinoin treatment compared to the pretreatment phase, decreasing from 75% to 43% in the temporal bulbar conjunctiva and from 100% to 82% in the superior bulbar conjunctiva. In both regions, the parameters most affected were cell-to-cell contact, nucleus-to-cytoplasm ratio, and goblet cell density.Conclusion: Oral isotretinoin for the treatment of acne induces alterations in the conjunctival epithelium of a significant percentage of patients treated with the drug. These alterations are seen both in the exposed conjunctiva (temporal bulbar region) and in the unexposed conjunctiva (superior bulbar region).
Keywords isotretinoin
adverse effects
keratoconjunctivitis sicca
Language English
Date 2009-10-01
Published in Cornea. Philadelphia: Lippincott Williams & Wilkins, v. 28, n. 9, p. 1009-1013, 2009.
ISSN 0277-3740 (Sherpa/Romeo, impact factor)
Publisher Lippincott Williams & Wilkins
Extent 1009-1013
Access rights Closed access
Type Article
Web of Science ID WOS:000271118400011

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