Obsessive-compulsive disorder: An open-label pilot trial of escitalopram

Obsessive-compulsive disorder: An open-label pilot trial of escitalopram

Author Almeida, Amanda Cristina Galvão Oliveira de Autor UNIFESP Google Scholar
Quarantini, Lucas de Castro Autor UNIFESP Google Scholar
Gois, Cristianne R. Google Scholar
Santos-Jesus, Rogerio Google Scholar
Miranda-Scippa, Ângela Marisa de Aquino Autor UNIFESP Google Scholar
Oliveira, Irismar R. de Google Scholar
Prado, Helena da Silva Autor UNIFESP Google Scholar
Leckman, James F. Google Scholar
Rosario, Maria Conceicao do Autor UNIFESP Google Scholar
Institution Universidade Federal da Bahia (UFBA)
Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Yale Univ
Abstract Introduction: Selective serotonin reuptake inhibitors are considered the most effective and well-established pharmacotherapy for the treatment of obsessive-compulsive disorder (OCD), a chronic and disabling condition. However, similar to 40% of patients do not have a significant improvement, suggesting that new medications are needed. This study was designed to investigate the treatment response to escitalopram in OCD patients.Methods: This open-label study involved 11 adult OCD outpatients diagnosed with the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders. Data were collected and the treatment response was assessed by an experienced psychiatrist by using the Yale-Brown Obsessive-Compulsive Scale. Subjects received escitalopram 30 mg/day for 12 weeks starting at 10 mg/day. Dosage adjustments were made within 2 weeks, depending on the tolerability of the patient.Results: Six of the 11 patients (54.5%) presented a reduction of at least 40% in the baseline total Yale-Brown Obsessive-Compulsive Scale scores.Conclusion: Despite the small sample size and the open-label nature of this trial, these data suggest that escitalopram may be a useful option for patients with OCD.
Language English
Date 2007-07-01
Published in Cns Spectrums. New York: M B L Communications, Inc, v. 12, n. 7, p. 519-524, 2007.
ISSN 1092-8529 (Sherpa/Romeo, impact factor)
Publisher M B L Communications, Inc
Extent 519-524
Origin https://doi.org/10.1017/S1092852900021258
Access rights Closed access
Type Article
Web of Science ID WOS:000249737300008
URI http://repositorio.unifesp.br/11600/43401

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