The Putative Impact of Metabolic Health on Default Mode Network Activity and Functional Connectivity in Neuropsychiatric Disorders

The Putative Impact of Metabolic Health on Default Mode Network Activity and Functional Connectivity in Neuropsychiatric Disorders

Author Cha, Danielle S. Google Scholar
De Michele, Francesco Google Scholar
Soczynska, Joanna K. Google Scholar
Woldeyohannes, Hanna O. Google Scholar
Kaidanovich-Beilin, Oksana Google Scholar
Carvalho, Andre F. Google Scholar
Malhi, Gin S. Google Scholar
Patel, Hiren Google Scholar
Sim, Kang Google Scholar
Brietzke, Elisa Autor UNIFESP Google Scholar
Mansur, Rodrigo Barbachan Autor UNIFESP Google Scholar
Dunlop, Katharine A. M. Google Scholar
Alsuwaidan, Mohammad Google Scholar
Baskaran, Anusha Google Scholar
Fagiolini, Andrea Google Scholar
Reznikov, Roman Google Scholar
Kudlow, Paul A. Google Scholar
McIntyre, Roger S. Google Scholar
Institution Univ Hlth Network
Univ Toronto
Univ Roma La Sapienza
Mt Sinai Hosp
Univ Fed Ceara
Univ Sydney
Ctr Addict & Mental Hlth
Natl Univ Singapore
Universidade Federal de São Paulo (UNIFESP)
Queens Univ
Univ Siena
Univ Western Ontario
Abstract The default mode network (DMN) describes a distributed network of brain regions that are predominantly activated and engaged during periods of spontaneous, stimulus independent thought (i.e., at rest) and remain quiescent during attention-demanding, goal-directed tasks. Replicated evidence in functional neuroimaging studies suggests that midline cortical and subcortical brain regions responsible for memory, self-relevant emotional and mental processes, as well as information integration comprise the DMN. The DMN is posited to represent self-referential mental activity via a dynamic interplay of cognitive and emotional processes by integrating information from the external environment with introspective thoughts to generate an autobiographical concept of the self.It has been amply documented that irregularities in the DMN and its functional connectivity are associated with various neuropsychiatric disorders. Moreover, accumulating evidence also suggests that individuals with select medical disorders (i.e., metabolic disorders) demonstrate alterations in DMN activity and functional connectivity. However, there is a paucity of data evaluating whether individuals with metabolically-based medical conditions, exhibiting altered DMN activity and functional connectivity, are at increased risk for developing neuropsychiatric disorders. Likewise, potential mechanisms (e.g., altered brain metabolism, insulin resistance) mediating these changes and their implications for novel treatment approaches have yet to be elucidated. Taken together, the overarching aim of this review is to provide a synthetic overview that suggests that this neural circuit may represent a common (or convergent) substrate affected in individuals with select neuropsychiatric and metabolic disorders.
Keywords Default mode network
functional connectivity
mental disorder
mood disorder
neurological disorder
neuropsychiatric disorder
resting state network
psychiatric disorder
task negative network
Language English
Date 2014-01-01
Published in Cns & Neurological Disorders-drug Targets. Sharjah: Bentham Science Publ Ltd, v. 13, n. 10, p. 1750-1758, 2014.
ISSN 1871-5273 (Sherpa/Romeo, impact factor)
Publisher Bentham Science Publ Ltd
Extent 1750-1758
Access rights Closed access
Type Article
Web of Science ID WOS:000348594400012

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