Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay

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dc.contributor.author Antonio, Eliana Maria Restum [UNIFESP]
dc.contributor.author Fontes, Tereza Maria Pereira [UNIFESP]
dc.contributor.author Simoes, Ricardo Santos [UNIFESP]
dc.contributor.author Carvalho, Adelino Moreira de [UNIFESP]
dc.contributor.author Espiridião, Silvia [UNIFESP]
dc.contributor.author Nakamura, Mary Uchiyama [UNIFESP]
dc.contributor.author Kulay Júnior, Luiz [UNIFESP]
dc.date.accessioned 2018-06-15T16:52:39Z
dc.date.available 2018-06-15T16:52:39Z
dc.date.issued 2012-01-01
dc.identifier http://www.irog.net/download/?magazine=21
dc.identifier.citation Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 205-208, 2012.
dc.identifier.issn 0390-6663
dc.identifier.uri http://repositorio.unifesp.br/11600/43294
dc.description.abstract Purpose: To evaluate the effects at term of a highly active antiretroviral drug association when administered for the whole period of rat pregnancy. Methods: Forty pregnant rats weighing about 200 g were randomly divided into four groups: a control group (Ctr = drug vehicle control, n = 10) and three experimental groups. which were treated with an oral solution of zidovudine-stavudine (Exp1x = 10/1 mg/kg b.w., n = 10; Exp3x = 30/3 mg/kg b.w., n = 10; Exp9x = 90/9 mg/kg b.w., n = 10) from day 0 up to the 20th day of pregnancy. Maternal body weights were recorded at the start of the experiment and on the 7th, 14th and 20th day thereafter. At term (20th day) the rats were anesthetized and submitted to hysterotomy. Implantations, reabsorptions, living fetuses, placentae and intrauterine deaths were looked for and recorded. The collected fetuses and placentae were weighed and the concepts were examined by a stereoscopic microscope looking for external malformations. Results: No significant alterations due to the antiretroviral drug treatment could be detected regarding the number of implantations, fetuses, placentae, absorptions and malformations nor regarding maternal and fetal mortality. Conclusions: Administration of the association zidovudine/stavudine for the whole period of rat pregnancy did not interfere with the maternal, fetal and placental weight gain as well as abnormalities detectable by the employed methodology. en
dc.format.extent 205-208
dc.language.iso eng
dc.publisher I R O G Canada, Inc
dc.relation.ispartof Clinical And Experimental Obstetrics & Gynecology
dc.rights Acesso aberto
dc.subject Rat en
dc.subject Pregnancy en
dc.subject Zidovudine en
dc.subject Stavudine en
dc.subject Adverse effects en
dc.title Effects of daily intake of zidovudine-stavudine on rat pregnancy outcome: biological essay en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.contributor.institution Jose do Rosario Vellano Univ
dc.contributor.institution ABC Med Fdn FUABC
dc.description.affiliation Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliation Univ Sao Paulo, Fac Med FMUSP, Dept Obstet, Sao Paulo, Brazil
dc.description.affiliation Jose do Rosario Vellano Univ, Sch Med, Dept Internal Med, Alfenas, MG, Brazil
dc.description.affiliation ABC Med Fdn FUABC, Dept Obstet & Pediat, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Sch Med UNIFESP EPM, Dept Obstet, Sao Paulo, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000304899500018



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