Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects

Interruption of a study of cervical ripening with isosorbide mononitrate due to adverse effects

Autor Hatanaka, Alan Roberto Autor UNIFESP Google Scholar
Moron, Antonio Fernandes Autor UNIFESP Google Scholar
Aquino, Márcia Maria Auxiliadora de Autor UNIFESP Google Scholar
Souza, E. de Autor UNIFESP Google Scholar
Bussamra, Luiz Claudio de Silva Autor UNIFESP Google Scholar
Araujo, E. Autor UNIFESP Google Scholar
Mattar, R. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Purpose of investigation: The objective of this study was to evaluate cervix length and the presence of cervical gland area (CGA) in ultrasounds performed before and after the administration of vaginal isosorbide mononitrate (IMN) for cervical ripening. Methods: We performed an observational, descriptive, and longitudinal study of pregnant patients indicated for labor induction and with a Modified Bishop Score (MBS) lower than six. For cervical ripening, 40 mg of vaginal IMN was administered at 0, 16, and 24 hours after the initiation of cervix preparation. Results: After enrolling 11 patients, the study had to be discontinued due to adverse effects. Three patients requested that they be withdrawn. Headaches were reported by all patients. Nausea, dizziness, dyspnea, and vomiting were also reported. The average cervical lengths at 0, 16, 24 and 36 hours were 27.6, 27.7, 25.9, and 23.0 mm, respectively. CGA disappeared in one of seven patients. Conclusions: The use of IMN appears to increase the MBS, slightly reducing cervical length without altering the appearance of CGA. Considering the importance of maternal wellbeing during labor, the routine use of IMN cannot be recommended for cervical ripening in the third trimester due to the frequency and intensity of side-effects.
Assunto Cervical ripening
Isosorbide
Adverse effects
Cervical length measurement
Induced labor
Idioma Inglês
Data 2012-01-01
Publicado em Clinical And Experimental Obstetrics & Gynecology. Montreal: I R O G Canada, Inc, v. 39, n. 2, p. 175-180, 2012.
ISSN 0390-6663 (Sherpa/Romeo, fator de impacto)
Editor I R O G Canada, Inc
Extensão 175-180
Fonte http://www.irog.net/download/?magazine=21
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000304899500011
URI http://repositorio.unifesp.br/11600/43293

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