BIOSYNTHESIS OF GLYCOSAMINOGLYCANS IN THE ENDOMETRIUM DURING THE INITIAL-STAGES OF PREGNANCY OF THE MOUSE

BIOSYNTHESIS OF GLYCOSAMINOGLYCANS IN THE ENDOMETRIUM DURING THE INITIAL-STAGES OF PREGNANCY OF THE MOUSE

Author Zorn, TMT Google Scholar
Pinhal, Maria Aparecida da Silva Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Carvalho, J. J. Google Scholar
Abrahamsohn, P. A. Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Significant changes in the synthesis of glycosaminoglycans occur during the transformation of stromal cells of the endometrium into decidual cells which takes place during the initial stages of pregnancy in mice. Hyaluronic acid, which is practically absent in the endometrium of virgin mice, increases dramatically on the fifth day of pregnancy, reaching its maximal concentration on day 6 followed by a 50% decrease on day 7. Changes in hyaluronic acid concentration also occur in pseudopregnant mice indicating that they are not related to the presence of the embryo in the uterus. The absolute concentration of the sulfated glycosaminoglycans, e.g., heparan sulfate, dermatan sulfate and chondroitin sulfate in the decidua did not change significantly. There was, however, a striking decrease of their biosynthesis in pregnant and pseudopregnant mice when compared to virgin mice, as shown by the use of radioactive inorganic sulfate as a precursor for the study of in vivo synthesis. A radioautographical analysis confirmed that the highest incorporation of radioactive sulfate was observed in virgin endometria when compared to pregnant ones. These studies also have shown a characteristic pattern of labeling in different regions of the endometrium that repeats itself during the different days of pregnancy.
Keywords GLYCOSAMINOGLYCANS
BIOSYNTHESIS
AUTORADIOGRAPHY
DECIDUA
MOUSE
Language English
Date 1995-02-01
Published in Cellular And Molecular Biology. Noisy-le-grand: Cellular & Molecular Biology, v. 41, n. 1, p. 97-106, 1995.
ISSN 0145-5680 (Sherpa/Romeo, impact factor)
Publisher Cellular & Molecular Biology
Extent 97-106
Access rights Closed access
Type Article
Web of Science ID WOS:A1995QJ06500011
URI http://repositorio.unifesp.br/11600/43258

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