Cytokines and pediatric open heart surgery with cardiopulmonary bypass

Cytokines and pediatric open heart surgery with cardiopulmonary bypass

Author Carvalho, Marcus Vinicius Henriques de Autor UNIFESP Google Scholar
Maluf, Miguel Angel Autor UNIFESP Google Scholar
Catani, Roberto Autor UNIFESP Google Scholar
La Rotta, CAA Google Scholar
Gomes, Walter José Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Silva, Celia Maria Carneiro Google Scholar
Carvalho, Antonio Carlos de Autor UNIFESP Google Scholar
Branco, João Nelson Rodrigues Autor UNIFESP Google Scholar
Buffolo, Enio Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract It is well known that, subsequent to cardiopulmonary bypass, and particularly in children, an inflammatory response within the body can often result in a characteristic syndrome. Recently, it has been suggested that this phenomenon is due to a systemic inflammatory response, with significant involvement of cytokines. With this in mind, we investigated the behavior of tumour necrosis factor-alpha and interleukin-6 during the operative and in the immediate postoperative period in a group of children submitted to Open heart surgery. We investigated any possible relation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, with the serum levels of lactate, and with the extent of use of inotropic drugs in postoperative period. The cytokines were measured in samples withdrawn after induction of anesthesia, after 10 minutes of cardiopulmonary bypass, after re-establishment of circulation, and then 2 and 24 hours after the end of cardiopulmonary bypass. The levels of tumour necrosis factor-a and interleukin-6 increased between the beginning and at two hours of the end of cardiopulmonary bypass. There was no correlation between the levels of these cytokines in the serum and the length of cardiopulmonary bypass, although there was a positive relation between levels of interleukin-6 and lactate in samples withdrawn at two hours of the end of bypass, and the measured levels of the cytokines correlated with the extent of inotropic drugs employed in the postoperative period.
Keywords cardiopulmonary bypass
cytokines
tumour necrosis factor-alpha and interleukin-6
surgery
cardiac
pediatric
Language English
Date 2001-01-01
Published in Cardiology In The Young. London: Greenwich Medical Media Ltd, v. 11, n. 1, p. 36-43, 2001.
ISSN 1047-9511 (Sherpa/Romeo, impact factor)
Publisher Greenwich Medical Media Ltd
Extent 36-43
Origin https://doi.org/10.1017/S1047951100012403
Access rights Closed access
Type Article
Web of Science ID WOS:000166564000007
URI http://repositorio.unifesp.br/11600/43248

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