Late auditory event-related evoked potential (P300) in Down's syndrome patients

Late auditory event-related evoked potential (P300) in Down's syndrome patients

Título alternativo Potencial evocado auditivo tardio relacionado a eventos (P300) na síndrome de Down
Autor César, Carla Patricia Hernandez Alves Ribeiro Autor UNIFESP Google Scholar
Caovilla, Heloisa Helena Autor UNIFESP Google Scholar
Autor UNIFESP Google Scholar
Ganança, Maurcio Malavasi Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Sao Paulo Bandeirante Univ
Resumo Down syndrome is caused by a trisomy of chromosome 21 and is associated with central auditory processing deficit, learning disability and, probably, early-onset Alzheimer's disease. Aim: to evaluate the latencies and amplitudes of evoked late auditory potential related to P300 events and their changes in young adults with Down's syndrome. Materials and Method: Prospective case study. P300 test latency and amplitudes were evaluated in 17 individuals with Down's syndrome and 34 healthy individuals. Results: The P300 latency (N1, P2, N2 and P3) was longer and the N2-P3 amplitude was lower in individuals with Down syndrome when compared to those in the control group. Conclusion: In young adults with Down syndrome, N1, P2, N2 and P3 latencies of late auditory evoked potential related to P300 events were prolonged, and N2 - P3 amplitudes were significantly reduced, suggesting integration impairment between the auditory association area and cortical and subcortical areas of the central nervous system.
Assunto down syndrome
p300
event-related potentials
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data 2010-03-01
Publicado em Brazilian Journal Of Otorhinolaryngology. Sao Paulo: Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial, v. 76, n. 2, p. 206-212, 2010.
ISSN 1808-8694 (Sherpa/Romeo, fator de impacto)
Editor Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial
Extensão 206-212
Fonte http://dx.doi.org/10.1590/S1808-86942010000200010
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000293572100010
SciELO S1808-86942010000200010 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/11600/43141

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