Synchronized order of appearance of hyaluronic acid (or acidic galactan)->chondroitin C-6 sulfate->chondroitin C-4/C-6 sulfate, heparan sulfate, dermatan sulfate->heparin during morphogenesis, differentiation and development

Synchronized order of appearance of hyaluronic acid (or acidic galactan)->chondroitin C-6 sulfate->chondroitin C-4/C-6 sulfate, heparan sulfate, dermatan sulfate->heparin during morphogenesis, differentiation and development

Author Nader, Helena Bonciani Autor UNIFESP Google Scholar
Oliveira, Fernanda Wanderley de Autor UNIFESP Google Scholar
Jeronimo, Selma Maria Bezerra Autor UNIFESP Google Scholar
Chavante, Suely Ferreira Autor UNIFESP Google Scholar
Sampaio, Lucia de Oliveira Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution UNIV FED RIO GRANDE NORTE
Universidade Federal de São Paulo (UNIFESP)
Abstract The synthesis of glycosaminoglycans and acidic polysaccharides during embryonic and fetal development in mammals and molluscs is briefly reviewed. A sequential order of appearance of each of the acidic polysaccharides was observed, coinciding with the major processes of the ontogeny. In mammals, hyaluronic acid is the first glycosaminoglycan synthesized at the beginning of morphogenesis. This glycosaminoglycan is then replaced by chondroitin 6-sulfate during the migration of the mesenchymal cells. Heparan sulfate, dermatan sulfate and chondroitin 4-sulfate are synthesized only during cell differentiation. The synthesis of heparin, on the other hand, is confined to mast cells in a few tissues and is a late event in the differentiation process. The same general pattern is also observed in molluscs except that hyaluronic acid is replaced by an acidic galactan in the morphogenetic process. The activity of the degrading enzymes responsible for the disappearance of hyaluronic acid, chondroitin sulfate and the acidic galactan in each phase of embryonic development is also reviewed.
Keywords embryonic development
acidic polysaccharides
fetal development
glycosaminoglycans
acidic galactan
mollusc embryogenesis
mammalian fetal development
chondroitin 6-sulfate
Language English
Date 1996-09-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 29, n. 9, p. 1221-1226, 1996.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1221-1226
Access rights Closed access
Type Article
Web of Science ID WOS:A1996VF23100017
URI http://repositorio.unifesp.br/11600/43115

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