EFFECTS OF ALMITRINE ON THE VENTILATORY CONTROL, BREATHING PATTERN AND MAXIMAL EXERCISE TOLERANCE IN HYPOXEMIC PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

EFFECTS OF ALMITRINE ON THE VENTILATORY CONTROL, BREATHING PATTERN AND MAXIMAL EXERCISE TOLERANCE IN HYPOXEMIC PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY-DISEASE

Author Ribeiro, S. A. Google Scholar
Jardim, José Roberto Autor UNIFESP Google Scholar
Romaldini, Helio Autor UNIFESP Google Scholar
Novo, Neil Ferreira Autor UNIFESP Google Scholar
Nery, Luiz Eduardo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Almitrine bismesylate improves arterial blood gases in patients with chronic obstructive pulmonary disease (COPD), but side effects such as increase of ventilatory drive and dyspnea have been reported in some studies. We studied 18 COPD patients (mean age = 59.1 years; mean FEV(1) = 0.92 1; mean PaO2 = 58.6 mmHg) in a double-blind randomized study using placebo or almitrine 50 mg twice a day by mouth, for 60 days. In contrast to the placebo group, 40% of the patients in the almitrine group presented a significant increase in PaO2 and a decrease in P(A-a)O-2 greater than or equal to 5 mmHg during submaximal exercise after 60 days of treatment. Ventilatory drive and the breathing pattern were measured at rest and during submaximal exercise. Both groups showed high levels of ventilatory drive and a tachypneic breathing pattern before drug treatment and no modification was found 30 and 60 days after treatment. Metabolic, cardiovascular and ventilatory variables were studied during an incremental to maximum exercise symptom-limited test (cycloergometry). Maximal VO2 ranged from 46 to 52% and heart rate from 76 to 78% in relation to the predicted values. The percent ratio of ventilation at maximal exercise to maximal voluntary ventilation at rest ranged from 86 to 94%. These results show that the reduction of ventilatory capacity was the main factor decreasing the aerobic performance of our COPD patients. Maximal exercise tolerance (VO2 max) did not change after almitrine treatment. Negative factors like an increase in neuromuscular drive did not occur, and positive factors like an increase in PaO2 and oxygen transport had no critical influence on exercise performance in our ventilatory-limited COPD patients.
Keywords ALMITRINE
HYPOXIA
CHRONIC OBSTRUCTIVE PULMONARY DISEASE
EXERCISE
VENTILATORY DRIVE
BREATHING PATTERN
Language English
Date 1995-08-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 28, n. 8, p. 859-867, 1995.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 859-867
Access rights Closed access
Type Article
Web of Science ID WOS:A1995RX53500004
URI http://repositorio.unifesp.br/11600/43089

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account