RADIOAEROSOL TC-99M-DTPA CHARACTERIZATION PRODUCED BY SOME NEBULIZERS

RADIOAEROSOL TC-99M-DTPA CHARACTERIZATION PRODUCED BY SOME NEBULIZERS

Author Medeiros, Regina Bitelli Autor UNIFESP Google Scholar
Nery, Luiz Eduardo Autor UNIFESP Google Scholar
Novo, Neil Ferreira Autor UNIFESP Google Scholar
Juliano, Yara Autor UNIFESP Google Scholar
Tabacniks, M. H. Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract 1. The radioacrosol Tc-99m-DTPA produced by jet and ultrasonic nebulizers was characterized by measuring the median mass diameter (MMD) and geometric standard deviation (sigma(g)) and these characteristics were interpreted in terms of the aerodynamic principles of inertial impactation.2. Jet nebulizers of the same model, with different outflows (NS(A) = 0.14 ml/min; NS(B) = 0.24 ml/min and NS(C) = 0.40 ml/min) showed different radioacrosol mass distribution, with MMD (NS(C)) > MMD (NS(A)). The ultrasonic nebulizer US-1000 from Narcosul, which is operated with an air flow of 2 l/min and frequency of 1.6 MHz, generated radioaerosol with MMD = 2.40 mum, higher than that obtained with most of the jet nebulizers evaluated (NS(A) = 1.50 mum; NS(B)1V = 1.40 mum; NS(B)2V = 1.20 mum and PITT#1 = 0.80 mum), and the ultrasonic nebulizer presented the highest outflow of the nebulized solution (1.15 ml/min).3. Connecting one or two impactation reservoirs to the NS(B) jet nebulizer modified the mass distribution, which became significantly narrower for NS(B)2V when compared to the other two nebulizers. NS(B)2V presented a mass percentage with a diameter of 3 mum or less and a sufficient outflow for use in ventilation and pulmonary permeability studies.4. Comparison of the mass collected in the cascade impactor and the total mass generated by the NS(B), NS(B)1V and NS(B)2V nebulizers showed, on average, 4.5% efficiency in radioacrosol generation with a diameter of less than 16 mum and 3.2% efficiency for a diameter of 3 mum or less.5. The PITT#1 nebulizer, generating 97% of the total nebulized mass with an MMD of 3 mum or less, showed the lowest outflow among the nebulizers tested (0.011 ml/min).
Keywords NEBULIZERS
RADIOAEROSOL
MEDIAN MASS DIAMETER
GEOMETRIC STANDARD DEVIATION
Language English
Date 1994-07-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 7, p. 1561-1573, 1994.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1561-1573
Access rights Closed access
Type Article
Web of Science ID WOS:A1994PA55200008
URI http://repositorio.unifesp.br/11600/43069

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