EFFECTS OF SINGLE AND LONG-TERM ADMINISTRATION OF NIFEDIPINE ON NOCICEPTION AND STEREOTYPED BEHAVIOR OF RATS

EFFECTS OF SINGLE AND LONG-TERM ADMINISTRATION OF NIFEDIPINE ON NOCICEPTION AND STEREOTYPED BEHAVIOR OF RATS

Autor Mattia, N. F. Google Scholar
Maiolini, M. Google Scholar
Conceição, Isaltino Marcelo da Autor UNIFESP Google Scholar
Chang, Y. H. Google Scholar
Smaili, Soraya Soubhi Autor UNIFESP Google Scholar
Frussa-Filho, Roberto Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In the present investigation, nociception and stereotyped behavior were evaluated in 3-month old male Wistar rats after a single nifedipine dose (2.5 and 5.0 mg/kg, ip, 1 h before testing, 6-7 rats per group for stereotypy studies and 15 animals per group for nociception experiments) or after long-term nifedipine treatment (2.5 mg/kg, ip, twice daily for 30 days,with testing performed 72 or 96 h after the last injection, 7 rats per group for stereotypy studies and 14-16 animals per group for nociception experiments). Stereotypy was induced with 2.5 mg/kg amphetamine, ip, and nociception was measured by the tail-immersion test. Administration of a single nifedipine dose did not modify nociception or amphetamine-induced stereotypy (with a mean +/- SEM tail-withdrawal latency of 4.5 +/- 0.5 s for control, 4.4 +/- 0.3 s for 2.5 mg/kg nifedipine and 4.7 +/- 0.7 s for 5.0 mg/kg nifedipine and with mean +/- SEM sum of stereotypy scores of 32.5 +/- 1.6 for control, 29.1 +/- 1.0 for 2.5 mg/kg nifedipine and 29.1 +/- 1.6 for 5.0 mg/kg nifedipine). Withdrawal from long-term nifedipine treatment did not affect stereotyped behavior (with mean +/- SEM sum of stereotypy scores of 28.7 +/- 1.6 for control and 30.7 +/- 1.3 for nifedipine-treated rats) but significantly increased tail-withdrawal latencies (with a mean +/- SEM tail-withdrawal latency of 4.1 +/- 0.3 s for control and 6.4 +/- 0.6 s for nifedipine-treated rats). Therefore, long-term nifedipine treatment induced plastic modifications in nociception but not in stereotyped behavior. The possible mechanisms underlying these results are discussed in the light of the effects of long-term calcium antagonist administration on the regulation of dopaminergic receptors and calcium channels.
Assunto NIFEDIPINE
CALCIUM CHANNEL BLOCKERS
AMPHETAMINE
STEREOTYPED BEHAVIOR
NOCICEPTION
Idioma Inglês
Data 1994-03-01
Publicado em Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 27, n. 3, p. 719-723, 1994.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Assoc Bras Divulg Cientifica
Extensão 719-723
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:A1994NB22600016
URI http://repositorio.unifesp.br/11600/43058

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