SERUM SEROTONIN LEVELS OF NORMAL AND AUTISTIC-CHILDREN

SERUM SEROTONIN LEVELS OF NORMAL AND AUTISTIC-CHILDREN

Author Naffah-Mazzacoratti, Maria da Graca Autor UNIFESP Google Scholar
Rosenberg, R. Google Scholar
Fernandes, MJS Google Scholar
Draque, Cecilia Maria Autor UNIFESP Google Scholar
Silvestrini, Wagner Sérgio Autor UNIFESP Google Scholar
Calderazzo, Lineu Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution GEPAPI
Universidade Federal de São Paulo (UNIFESP)
Abstract 1. Serum serotonin (5HT) was determined in normal and autistic children by high performance liquid chromatography with electrochemical detection (HPLC-ED), after serum deproteinization.2. The sample deproteinization was carried out by the addition of 3.4 M HCLO4 to a small volume of the serum, followed by freezing, centrifugation, dilution and injection of sample into the HPLC.3. Serum 5HT concentration was significantly increased in autistic children (303 +/- 92 ng/ml) (N = 19) when compared to that of normal children (215 +/- 67 ng/ml) (N = 46). The data of normal children analyzed by ANOVA for sex or age showed no difference.4. The method employed in this study showed high resolution, good sensitivity and can be used for routine determination of serum 5HT in the clinical investigation of hyperserotonemia in autism.
Keywords SEROTONIN
LIQUID CHROMATOGRAPHY
AUTISM
Language English
Date 1993-03-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 26, n. 3, p. 309-317, 1993.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 309-317
Access rights Closed access
Type Article
Web of Science ID WOS:A1993KZ43800008
URI http://repositorio.unifesp.br/11600/43037

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