USE OF AMPICILLIN PLUS RANITIDINE FOR HELICOBACTER-PYLORI GASTRITIS

USE OF AMPICILLIN PLUS RANITIDINE FOR HELICOBACTER-PYLORI GASTRITIS

Author Ferrari, APJ Google Scholar
Geocze, Stephan Autor UNIFESP Google Scholar
Lanzoni, VPB Google Scholar
Toledo, Maria Regina Fernandes de Autor UNIFESP Google Scholar
Trabulsi, Luiz Rachid Autor UNIFESP Google Scholar
Vilela, Moacyr Padua Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract 1. Helicobacter pylori (formerly Campylobacter pylori) is now recognized as an etiological factor in gastritis and duodenal ulcers and probably also gastric ulcers. Eradication of the bacteria is fundamental to avoid ulcer relapse. Although bismuth salts have been shown to be effective for treatment, they are not commercially available in Brazil.2. We report an attempt to treat patients with Helicobacter pylori-associated gastritis with ampicillin (1000 mg twice daily for one month) and compare the results with the conventional treatment used in Brazil (ranitidine, 300 mg daily for one month) and with a combination of the two drugs. We studied 44 patients with histologically confirmed gastritis and with Helicobacter pylori, who were examined at the beginning and after one month of treatment.3. Ampicillin associated with ranitidine was better than ampicillin or ranitidine alone for the treatment of gastritis. Although ampicillin may be more efficient in patients with lower acid output we did not find a statistically significant difference between these two groups (ampicillin vs drug combination), perhaps owing to the small number of patients studied. When ampicillin was combined with ranitidine there was 25 % normalization of the histological picture of the gastric mucosa.4. We conclude that ampicillin in combination with ranitidine may be a useful treatment for Helicobacter pylori-associated gastritis.
Keywords HELICOBACTER-PYLORI
GASTRITIS
AMPICILLIN
RANITIDINE
GASTRODUODENAL DISEASE
Language English
Date 1991-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 6, p. 567-572, 1991.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 567-572
Access rights Closed access
Type Article
Web of Science ID WOS:A1991GC18700004
URI http://repositorio.unifesp.br/11600/43005

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