INFLAMMATORY RESPONSE MODULATED BY PINEALECTOMY - EFFECT OF LIGHT

INFLAMMATORY RESPONSE MODULATED BY PINEALECTOMY - EFFECT OF LIGHT

Author Lobo, Renato Andreucci Autor UNIFESP Google Scholar
Limaos, Elias Augusto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract In view of the known interactions between pineal and adrenal glands and the importance of glucocorticoids on the acute phase of the inflammatory process, we investigated the effect of the pineal gland on the paw edema response induced by carrageenin in female Wistar rats, weighing 170-220 g, measured by the pletysmographic method. Adrenalectomy increased the rate of the inflammatory response (149.02 +/- 2.93%, N = 7 vs 113.48 +/- 2.99%, N = 7) whereas pinealectomy and sham-pinealectomy under white light had an inhibitory effect (81.73 +/- 2.16%, N = 15 and 80.21 +/- 1.85%, N = 14 vs 113.48 +/- 2.99%, N = 7). Sham-pinealectomy under red light did not modify the rate of the inflammatory response. These results indicate that the pineal gland can be affected by light during sham-pinealectomy. In view of the unaltered adrenal gland weight and corticosterone levels among the different groups, we propose an antagonism between melatonin (pineal hormone) and glucocorticoids at the peripheral level. The predominant effect of glucocorticoids over melatonin may explain the inhibition of the inflammatory response caused by pinealectomy.
Keywords PINEAL GLAND
ADRENAL GLAND
MELATONIN
GLUCOCORTICOIDS
INFLAMMATION
ACUTE PHASE REACTION
Language English
Date 1991-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 11, p. 1159-1162, 1991.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1159-1162
Access rights Closed access
Type Article
Web of Science ID WOS:A1991GW65200013
URI http://repositorio.unifesp.br/11600/43002

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