NATIVE PLASMA KALLIKREIN IS CLEARED AT SIMILAR RATES BY MAMMALIAN AND AVIAN LIVERS

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dc.contributor.author Borges, Durval Rosa [UNIFESP]
dc.contributor.author Kouyoumdjian, Maria [UNIFESP]
dc.contributor.author Limaos, Elias Augusto [UNIFESP]
dc.date.accessioned 2018-06-15T14:28:00Z
dc.date.available 2018-06-15T14:28:00Z
dc.date.issued 1991-01-01
dc.identifier.citation Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 1, p. 63-65, 1991.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/11600/42993
dc.description.abstract Rat plasma kallikrein (RPK) is a serine protease that circulates as an inactive precursor, prokallikrein, and once activated is efficiently cleared by the liver by a carbohydrate-dependent, Ca2+ -independent mechanism. Seven hepatic lectin systems have been described for mammals but not all of these animal lectins are expressed in the avian liver. Using a liver perfusion system we compared the plasma kallikrein clearance of rats (N = 10) and pigeons (N = 4). Our results show that the lectin responsible for the hepatic clearance of plasma kallikrein is also present in pigeon liver and that this organ clears the enzyme with an efficiency (11.4 +/- 1.3 pmol/g, 20 min) similar to that of the rat liver (10.0 +/- 0.7 pmol/g, 20 min). en
dc.format.extent 63-65
dc.language.iso eng
dc.publisher Assoc Bras Divulg Cientifica
dc.relation.ispartof Brazilian Journal Of Medical And Biological Research
dc.rights Acesso restrito
dc.subject PLASMA KALLIKREIN en
dc.subject HEPATIC CLEARANCE en
dc.subject MAMMALIAN LIVER en
dc.subject AVIAN LIVER en
dc.title NATIVE PLASMA KALLIKREIN IS CLEARED AT SIMILAR RATES BY MAMMALIAN AND AVIAN LIVERS en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT BIOQUIM,DISCIPLINA GASTROENTEROL CLIN,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliation ESCOLA PAULISTA MED SCH,DEPT FISIOL,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT BIOQUIM,DISCIPLINA GASTROENTEROL CLIN,BR-04023 SAO PAULO,BRAZIL
dc.description.affiliationUnifesp ESCOLA PAULISTA MED SCH,DEPT FISIOL,BR-04023 SAO PAULO,BRAZIL
dc.description.source Web of Science
dc.identifier.wos WOS:A1991EX63600009



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