NATIVE PLASMA KALLIKREIN IS CLEARED AT SIMILAR RATES BY MAMMALIAN AND AVIAN LIVERS

NATIVE PLASMA KALLIKREIN IS CLEARED AT SIMILAR RATES BY MAMMALIAN AND AVIAN LIVERS

Author Borges, Durval Rosa Autor UNIFESP Google Scholar
Kouyoumdjian, Maria Autor UNIFESP Google Scholar
Limaos, Elias Augusto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Rat plasma kallikrein (RPK) is a serine protease that circulates as an inactive precursor, prokallikrein, and once activated is efficiently cleared by the liver by a carbohydrate-dependent, Ca2+ -independent mechanism. Seven hepatic lectin systems have been described for mammals but not all of these animal lectins are expressed in the avian liver. Using a liver perfusion system we compared the plasma kallikrein clearance of rats (N = 10) and pigeons (N = 4). Our results show that the lectin responsible for the hepatic clearance of plasma kallikrein is also present in pigeon liver and that this organ clears the enzyme with an efficiency (11.4 +/- 1.3 pmol/g, 20 min) similar to that of the rat liver (10.0 +/- 0.7 pmol/g, 20 min).
Keywords PLASMA KALLIKREIN
HEPATIC CLEARANCE
MAMMALIAN LIVER
AVIAN LIVER
Language English
Date 1991-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 24, n. 1, p. 63-65, 1991.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 63-65
Access rights Closed access
Type Article
Web of Science ID WOS:A1991EX63600009
URI http://repositorio.unifesp.br/11600/42993

Show full item record




File

File Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Search


Browse

Statistics

My Account