SOME EVIDENCE THAT INTRAHIPPOCAMPAL GRAFTING OF NORADRENERGIC NEURONS SUPPRESSES SPONTANEOUS SEIZURES IN EPILEPTIC RATS

SOME EVIDENCE THAT INTRAHIPPOCAMPAL GRAFTING OF NORADRENERGIC NEURONS SUPPRESSES SPONTANEOUS SEIZURES IN EPILEPTIC RATS

Author Bortolotto, Zuner Assis Autor UNIFESP Google Scholar
Calderazzo, Lineu Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Pilocarpine-induced status epilepticus leads to widespread limbic forebrain damage in rats and provides a model for studying intractable epilepsy. Noradrenergic neurons in suspension, prepared from the locus coeruleus region of donors on the 13th or 14th gestational day, were microinjected bilaterally into the hippocampus (8 rats) and into the cerebellum (4 rats) or the olfactory bulb (4 rats) of epileptic rats. Three mu-l of suspension was deposited at the rate of 1-mu-l/min. Control animals were not submitted to surgery (4 rats). After six weeks a marked reduction of suppression of spontaneous seizures was observed in intrahippocampally grafted rats. From these preliminary results we suggest that grafts can be used to suppress spontaneous recurrent epileptic seizures.
Keywords PILOCARPINE
SPONTANEOUS SEIZURE
HIPPOCAMPUS
NORADRENERGIC NEURONS
Language English
Date 1990-01-01
Published in Brazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 23, n. 12, p. 1267-1269, 1990.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Assoc Bras Divulg Cientifica
Extent 1267-1269
Access rights Closed access
Type Article
Web of Science ID WOS:A1990EP27200009
URI http://repositorio.unifesp.br/11600/42976

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