Título alternativo | Effects in short-term of alloxan application to diabetes induction in Wistar rats |
Autor |
Leme, Jose Alexandre Curiacos de Almeida
![]() Castellar, Alexandre ![]() Remedio, Rafael Neodini ![]() Barbosa, Rodrigo Avelaira ![]() Moura, Leandro Pereira de ![]() Dalia, Rodrigo Augusto ![]() Gomes, Ricardo Jose ![]() ![]() Caetano, Flavio Henrique ![]() Mello, Maria Alice Rostom de ![]() Luciano, Eliete ![]() |
Instituição | Univ Estadual Paulista Universidade Federal de São Paulo (UNIFESP) |
Resumo | The present study aimed to verify action of alloxan in metabolic and immune parameters after 24 and 192 hours of the injection in Wistar rats. Thus, eight rats were fasted and received monohidrated alloxan Sigma (32 mg/kg body weight) via endovenous. Glycemia and trglyceridemia analyzes were performed before and 192 hours after alloxan application. After 24 hours, alloxan application increased water intake and decreased body mass, food intake and leucocytes counting. 192 hours after alloxan application, there was a recuperation in food intake and leucocytes counting. On the other hand, in this period there was an increase of glycemia and water intake and reduction of body mass. These results indicate that some of diabetic signs caused by alloxan occur in short-term after drug administration. |
Assunto |
Alloxan
Diabetes Metabolism Immune System |
Idioma | Português |
Data | 2010-05-01 |
Publicado em | Bioscience Journal. Uberlandia: Univ Federal Uberlandia, v. 26, n. 3, p. 442-447, 2010. |
ISSN | 1516-3725 (Sherpa/Romeo, fator de impacto) |
Editor | Univ Federal Uberlandia |
Extensão | 442-447 |
Fonte |
|
Direito de acesso | Acesso aberto ![]() |
Tipo | Artigo |
Web of Science | WOS:000282056200015 |
URI | http://repositorio.unifesp.br/11600/42839 |
Nome:
WOS000282056200015.pdf
Tamanho: 119.6Kb Formato: PDF Descrição: |
Visualizar/ |