Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia

Effects of isoflavone on oxidative stress parameters and homocysteine in postmenopausal women complaining of insomnia

Author Brandao, Leticia de Campos Autor UNIFESP Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
D'Almeida, Vania Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Sleep disorders have an increased incidence after menopause. The objective of this work was to evaluate the effects of isoflavone on some oxidative stress markers in postmenopausal women complaining of insomnia. Women aged between 50-65 years (n=38) were recruited and assigned to a double-blind placebo controlled study for 4 months. The treated group received 100 mg/day of isoflavones. Blood collections were conducted on three different occasions to assess total gluthathione; superoxide dismutase and catalase in erythrocytes; lipid peroxidation; and homocysteine plasma concentrations. No differences between the groups were observed. However, all the patients seem to improve their oxidative stress Status and homocysteine concentration after treatment. Superoxide dismutase activity was correlated with age and time of menopause at the beginning of the treatment, but these correlations were no longer observed by the end of the study. Soy isoflavones were not able to overcome the placebo effect for either oxidative stress parameters or homocysteine concentrations.
Keywords homocysteine
isoflavones
insomnia
menopause
oxidative stress
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
AFIP FADA-UNIFESP
Zambon Group
Date 2009-01-01
Published in Biological Research. Santiago: Soc Biolgia Chile, v. 42, n. 3, p. 281-287, 2009.
ISSN 0716-9760 (Sherpa/Romeo, impact factor)
Publisher Soc Biolgia Chile
Extent 281-287
Origin http://dx.doi.org/10.4067/S0716-97602009000300002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000270893400002
SciELO ID S0716-97602009000300002 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42822

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