Apomorfina: uma alternativa no controle das flutuações motoras na doença de Parkinson

Apomorfina: uma alternativa no controle das flutuações motoras na doença de Parkinson

Alternative title APOMORPHINE - AN ALTERNATIVE IN THE MANAGEMENT OF MOTOR FLUCTUATIONS OF PARKINSONS-DISEASE
Author Ferraz, Henrique Ballalai Autor UNIFESP Google Scholar
Silva, Sonia Maria de Azevedo Autor UNIFESP Google Scholar
Borges, Vanderci Autor UNIFESP Google Scholar
Rocha, Maria Sheila Guimarães Autor UNIFESP Google Scholar
Andrade, Luiz Augusto Franco de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Levodopa-induced motor fluctuations (MF) is a disabling complication of Parkinson's disease (PD) and is usually refractory to conventional treatment. Apomorphine, a dopamine agonist with affinity for both D1 and D2 receptors, has been emerged as an useful alternative in the management of MF of PD. The frequency of nausea and vomiting prevented its use in the past, but the simultaneous administration of domperidone has proved to be able to control these side effects. Although apomorphine has been successfully used to control levodopa-induced MF in other countries, it has not been considered in the management of PD in Brazil. We report here our initial experience with subcutaneous injections of apomorphine combined to oral domperidone. We administered apomorphine in doses ranging from 1.5 to 3 mg in four PD patients with MF of our outpatient clinic. All the doses administered switched the ''off'' state to a motor response qualitatively similar to what is seen in the ''on'' phase induced by levodopa, including the occurrence of dyskinesia. The latency to turn ''on'' after apomorphine ranged from 7 to 30 minutes and the duration of the response ranged from 60 to 85 minutes. We observed yawning in all four patients, labial paresthesia in one patient and an inespecific unpleasent sensation in another patient. These side effects were not significant in our four patients. Our data show that the use of apomorphine adds a reliable and effective strategy in the management of MF of PD patients.
Keywords PARKINSONS DISEASE, TREATMENT
APOMORPHINE, THERAPEUTIC USE
LEVODOPA, ADVERSE EFFECTS
Language Portuguese
Date 1995-06-01
Published in Arquivos De Neuro-psiquiatria. Sao Paulo Sp: Assoc Arquivos De Neuro- Psiquiatria, v. 53, n. 2, p. 245-251, 1995.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Assoc Arquivos De Neuro- Psiquiatria
Extent 245-251
Origin http://dx.doi.org/10.1590/S0004-282X1995000200010
Access rights Open access Open Access
Type Article
Web of Science ID WOS:A1995RB33500010
SciELO ID S0004-282X1995000200010 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42728

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