Parathyroid carcinoma and hungry bone syndrome

Parathyroid carcinoma and hungry bone syndrome

Alternative title Carcinoma de paratiroide e fome óssea
Author Ohe, Monique Nakayama Autor UNIFESP Google Scholar
Santos, Rodrigo Oliveira Autor UNIFESP Google Scholar
Hojaij, Flavio Carneiro Autor UNIFESP Google Scholar
Neves, Murilo Catafesta Autor UNIFESP Google Scholar
Kunii, Ilda Sizue Autor UNIFESP Google Scholar
Orlandi, Denise Autor UNIFESP Google Scholar
Valle, Luisa Autor UNIFESP Google Scholar
Martins, Carla Autor UNIFESP Google Scholar
Janovsky, Carolina Castro Porto Silva Autor UNIFESP Google Scholar
Ferreira, Rimarcs Gomes Autor UNIFESP Google Scholar
Delcelo, Roseane Autor UNIFESP Google Scholar
Domingos, Ana Maria Autor UNIFESP Google Scholar
Abrahão, Márcio Autor UNIFESP Google Scholar
Cervantes, Onivaldo Autor UNIFESP Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Vieira, Jose Gilberto Henriques Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract We hereby report two patients with parathyroid carcinoma presenting extremely high calcium and PTH levels, severe bone disease, and palpable neck mass at diagnosis. They both underwent parathyroidectomy, and one of them evolved to lung metastasis. Important hypocalcemia was observed after surgery in both: after parathyroidectomy in one patient, and only after surgical removal of the metastasis in the other. Both required intravenous calcium replacement, thus revealing hungry bone syndrome (HBS). HBS usually reflects rapid mineralization after correction of hyperparathyroidism. The more severe the bone disease before surgery, the more prone the patient is to HBS after surgery. Despite being an unfavorable outcome, HBS state suggests that surgical removal of hypersecretory parathyroid tissue was accomplished. In this study, HBS was observed in both patients, who presented severe bone disease prior to surgery. HBS would be expected post-operatively in successful parathyroid carcinoma removal. Arq Bras Endocrinol Metab. 2013; 57(1):79-86
Language English
Date 2013-02-01
Published in Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 57, n. 1, p. 79-86, 2013.
ISSN 0004-2730 (Sherpa/Romeo, impact factor)
Publisher Sbem-soc Brasil Endocrinologia & Metabologia
Extent 79-86
Origin http://dx.doi.org/10.1590/S0004-27302013000100011
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000315334000011
SciELO ID S0004-27302013000100011 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42711

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