Near-final height in patients with congenital adrenal hyperplasia treated with combined therapy using GH and GnRHa

Near-final height in patients with congenital adrenal hyperplasia treated with combined therapy using GH and GnRHa

Alternative title Altura quase normal em pacientes com hiperplasia adrenal congênita tratados com a combinação de GH e GnRHa
Author Longui, Carlos Alberto Google Scholar
Kochi, Cristiane Google Scholar
Calliari, Luis Eduardo Procopio Autor UNIFESP Google Scholar
Modkovski, Maria Barcellos Rosa Google Scholar
Soares, Marisa Google Scholar
Alves, Erica Ferreira Google Scholar
Prudente, Fernanda Vilas Boas Google Scholar
Monte, Osmar Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Introduction: Intrinsic limitations of glucocorticoid therapy in patients with congenital adrenal hyperplasia (CAH) determine frequent loss in final height. The association of secondary central precocious puberty and early epiphyseal fusion is also frequent. In these conditions, GnRHa treatment alone or in combination with GH has been indicated. Objectives: This is a retrospective study, describing the estatural findings of CAH patients with significant decrease in height prediction, who were submitted to combined GH plus GnRHa therapy up to near-final height. Subjects and methods: We studied 13 patients, eight females and five males, eight with the classical and five with the nonclassical form of the disorder. Treatment with hydrocortisone (10-20 mg/m(2)/day) or prednisolone (3-6 mg/kg/day) was associated with GnRHa (3.75 mg/months) for 4.0 (1.5) years, and GH (0.05 mg/kg/day) for 3.6 (1.4) years. Results: Stature standard deviation score for bone age improved significantly after GH treatment, becoming similar to target height at the end of the second year of GH treatment. Conclusion: We conclude that combined GH plus GnRHa therapy can be useful in a subset of CAH patients with significant reduction of predicted final height associated with poor hormonal control and central precocious puberty. Arq Bras Endocrinol Metab. 2011;55(8):661-4
Keywords GH
GnRHa
congenital adrenal hyperplasia
height
growth recovery
Language English
Date 2011-11-01
Published in Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 55, n. 8, p. 661-664, 2011.
ISSN 0004-2730 (Sherpa/Romeo, impact factor)
Publisher Sbem-soc Brasil Endocrinologia & Metabologia
Extent 661-664
Origin http://dx.doi.org/10.1590/S0004-27302011000800023
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000298885900023
SciELO ID S0004-27302011000800023 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42710

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