Heterogeneidade clínica e coexistência das neuropatias diabéticas: diferenças e semelhanças entre diabetes melito tipos 1 e 2

Heterogeneidade clínica e coexistência das neuropatias diabéticas: diferenças e semelhanças entre diabetes melito tipos 1 e 2

Alternative title Clinical heterogeneity and coexistence of diabetic neuropathies: difference and similarities between types 1 and 2 diabetes mellitus
Author Rolim, Luiz Clemente de Souza Pereira Autor UNIFESP Google Scholar
Sá, João Roberto de Autor UNIFESP Google Scholar
Chacra, Antonio Roberto Autor UNIFESP Google Scholar
Dib, Sergio Atala Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: To evaluate the heterogeneity and the coexistence of diabetic neuropathy (DNP) in type 1 (T1DM) and 2 (T2DM) diabetes mellitus. Methods: 74 T2DM and 20 T1DM patients were evaluated according to age (years), time from diagnosis of diabetes (TDD, years), body mass index (BMI, kg/m(2)), HbA1c and DNP type (American Diabetes Association criteria). Results: T1DM was younger (32.7 +/- 11.0 versus 56.9 +/- 10.3; p = 0.0001), leaner (BM: 23.6 +/- 3.85 versus 28.4 +/- 5.3; p = 0.0005) and they had longer TDD (171 +/- 9.7 versus 10.4 +/- 6.8; p = 0.003). Cardiovascular autonomic neuropathy (CAN) (60% versus 32.4%; p = 0.02) and its coexistence with polyneuropathy (PN) (62.5% versus 33.3%; p = 0.03) were more common in T1DM. Chronic painful polyneuropathy (CPP) was more prevalent in T2DM (60.8% versus 30.0%; p = 0.009). Logistic regression showed HbA1c as an independent variable related to PN (p = 0.04) in both groups. TDD (p = 0.03) and CPP (p = 0.003) were related to CAN in T1DM. Age (p = 0.0004) was related to CPP in T2DM. Conclusions: The DNP have shown a heterogeneity distribution in type 1 and type 2 diabetes mellitus. The related factors to different phenotypes of this complication, apart from hyperglycemia, may be variable between these two types of diabetes mellitus. Arq Bras Endocrinol Metalb. 2009;53(7):818-24
Keywords Diabetes mellitus
diabetic neuropathies
Language Portuguese
Date 2009-10-01
Published in Arquivos Brasileiros De Endocrinologia E Metabologia. Rio De Janeiro, Rj: Sbem-soc Brasil Endocrinologia & Metabologia, v. 53, n. 7, p. 818-824, 2009.
ISSN 0004-2730 (Sherpa/Romeo, impact factor)
Publisher Sbem-soc Brasil Endocrinologia & Metabologia
Extent 818-824
Origin http://dx.doi.org/10.1590/S0004-27302009000700005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000271389100005
SciELO ID S0004-27302009000700005 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42704

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