Polymorphism of Interleukin-6 Is Not Associated with the Presence or Absence of High HPV E6/E7

Polymorphism of Interleukin-6 Is Not Associated with the Presence or Absence of High HPV E6/E7

Autor Porto, Claudia Regina Cinti Correa Autor UNIFESP Google Scholar
Kleine, Joao Paulo Ferreira de Oliveira Autor UNIFESP Google Scholar
Longatto-Filho, Adhemar Google Scholar
Silva, Ismael Dale Cotrim Guerreiro da Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Pio XII Fdn
Universidade de São Paulo (USP)
Univ Minho
Govt Associate Lab
Resumo The present study evaluated the frequency of the polymorphism of Interleukin-6 (IL6) in women positive for E6/E7 Human Papillomavirus (HPV) (n=152) and women negative for HPV (n=238), 390 women in total. Material for analysis was obtained at the Federal University of Sao Paulo. Interleukin-6 polymorphism was detected by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) and analyzed in 3% agarose gel. Results: No significant associations between the frequency of the polymorphism of IL6 in patients expressing E6 and E7 with HPV-positive and -negative reactions were found. There was no statistically significant difference between the case and control group for genotype distribution (p=0.280). Conclusion: Genotypic analysis showed a striking similarity of IL6 polymorphisms in both cases and controls. The allelic distribution in cases and controls for G and C of IL6 were very similar (p=0.186), which could point to similar IL6 functionality for both groups.
Assunto Gene polymorphism
IL6
HPV
E6/E7
Idioma Inglês
Data 2014-07-01
Publicado em Anticancer Research. Athens: Int Inst Anticancer Research, v. 34, n. 7, p. 3501-3504, 2014.
ISSN 0250-7005 (Sherpa/Romeo, fator de impacto)
Editor Int Inst Anticancer Research
Extensão 3501-3504
Fonte http://ar.iiarjournals.org/content/34/7/3501.abstract
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000338780300034
URI http://repositorio.unifesp.br/11600/42603

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