Author |
Queiroz, Ana Beatriz Piazza
![]() ![]() Focchi, Gustavo Rubino de Azevedo ![]() ![]() Dobo, Cristine ![]() ![]() Gomes, Thiago Simao ![]() ![]() Ribeiro, Daniel Araki ![]() ![]() Oshima, Celina Tizuko Fujiyama ![]() ![]() |
Institution | Universidade Federal de São Paulo (UNIFESP) |
Abstract | Aim: To characterize the immunohistochemical expression of p27, p21(WAF/CiP1) and p16(INK4a) in normal oral epithelium, oral squamous pcipilloma and oral squamous cell carcinoma. Materials and Methods: hnmunohistochemical staining for p27, p21(WAF/Cip1) and p16(INK4a) was evaluated in 32 samples of normal oral squamous epithelium, 30 samples of oral squamous papilloma, and 34 samples of oral squamous cell carcinoma. Results: Statistically significant differences (p<0.05) were found in p27 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Regarding p21(WAF/Cip1) expression, no statistically significant differences (p>0.05) were noticed. In the same way, no significant statistically differences (p>0.05) were observed for p16(INK4a) among groups. Conclusion: Taken together, these findings indicate that p27 is closely involved in malignant transformation of oral mucosa cells, and may be a reliable biomarker for this purpose. |
Language | English |
Date | 2010-07-01 |
Published in | Anticancer Research. Athens: Int Inst Anticancer Research, v. 30, n. 7, p. 2799-2803, 2010. |
ISSN | 0250-7005 (Sherpa/Romeo, impact factor) |
Publisher | Int Inst Anticancer Research |
Extent | 2799-2803 |
Origin |
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Access rights | Open access ![]() |
Type | Article |
Web of Science ID | WOS:000280796400044 |
URI | http://repositorio.unifesp.br/11600/42597 |
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