Expression of p27, p21(WAF/Cip1) and pl6(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma

Expression of p27, p21(WAF/Cip1) and pl6(INK4a) in Normal Oral Epithelium, Oral Squamous Papilloma, and Oral Squamous Cell Carcinoma

Author Queiroz, Ana Beatriz Piazza Autor UNIFESP Google Scholar
Focchi, Gustavo Rubino de Azevedo Autor UNIFESP Google Scholar
Dobo, Cristine Autor UNIFESP Google Scholar
Gomes, Thiago Simao Autor UNIFESP Google Scholar
Ribeiro, Daniel Araki Autor UNIFESP Google Scholar
Oshima, Celina Tizuko Fujiyama Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Aim: To characterize the immunohistochemical expression of p27, p21(WAF/CiP1) and p16(INK4a) in normal oral epithelium, oral squamous pcipilloma and oral squamous cell carcinoma. Materials and Methods: hnmunohistochemical staining for p27, p21(WAF/Cip1) and p16(INK4a) was evaluated in 32 samples of normal oral squamous epithelium, 30 samples of oral squamous papilloma, and 34 samples of oral squamous cell carcinoma. Results: Statistically significant differences (p<0.05) were found in p27 expression when comparing ordinary mucosa and oral squamous papilloma with the oral squamous cell carcinoma samples. Regarding p21(WAF/Cip1) expression, no statistically significant differences (p>0.05) were noticed. In the same way, no significant statistically differences (p>0.05) were observed for p16(INK4a) among groups. Conclusion: Taken together, these findings indicate that p27 is closely involved in malignant transformation of oral mucosa cells, and may be a reliable biomarker for this purpose.
Language English
Date 2010-07-01
Published in Anticancer Research. Athens: Int Inst Anticancer Research, v. 30, n. 7, p. 2799-2803, 2010.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 2799-2803
Origin http://ar.iiarjournals.org/content/30/7/2799.long
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000280796400044
URI http://repositorio.unifesp.br/11600/42597

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