Texture Image Analysis in Differentiating Malignant from Benign Adrenal Cortical Tumors in Children and Adults

Texture Image Analysis in Differentiating Malignant from Benign Adrenal Cortical Tumors in Children and Adults

Author Shirata, N. K. Google Scholar
Sredni, S. T. Google Scholar
Castelo, A. Autor UNIFESP Google Scholar
Santinelli, A. Google Scholar
Mendonca, B. Google Scholar
Montironi, R. Google Scholar
Longatto Filho, A. Google Scholar
Zerbini, M. C. N. Google Scholar
Institution Universidade de São Paulo (USP)
Adolfo Lutz Inst
Northwestern Univ
Universidade Federal de São Paulo (UNIFESP)
Postdoctoral Fellowship Univ Minho
Abstract Objective: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT). Patients and Methods: Forty-eight cases of clinically benign (n=40) and clinically malignant (n=8) ACT with a minimum of 5-years' follow-up were evaluated for chromatin texture parameters (run length, standard deviation, configurable run length, valley, slope, peak and other 21 Markovian features that describe the distribution of the chromatin in the nucleus), nuclear morphology (nuclear area, nuclear perimeter, nuclear maximum and minumum diameter, nuclear shape), and DNA ploidy. Nuclear parameters were evaluated in Feulgen-stained 5 mu m paraffin-sections analyzed using a CAS 200 image analyzer. Results: Since ACTs present different biological features in children and adults, patients were divided into two groups: children (<= 15 years) and adults (>15 years). In the group of children DNA ploidy presented a marginal significance (p=0.05) in discriminating ACTs. None of the parameters discriminated between malignant and benign ACT in the adult group. Conclusion: ACTs are uncommon and definitive predictive criteria for malignancy remain uncertain, particularly in children. Our data point to DNA content evaluated by image analysis as a new candidate tool for this challenging task. Texture image analysis did not help to differentiate malignant from benign adrenal cortical tumors in children and adults.
Keywords Adrenocortical tumors
adrenal
image analysis
chromatin texture
nuclear morphology
DNA ploidy
children
adults
Language English
Date 2009-08-01
Published in Anticancer Research. Athens: Int Inst Anticancer Research, v. 29, n. 8, p. 3365-3368, 2009.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 3365-3368
Origin http://ar.iiarjournals.org/content/29/8/3365.long
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000268846800068
URI http://repositorio.unifesp.br/11600/42596

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