Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma

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dc.contributor.author Calcagno, Danielle Queiroz [UNIFESP]
dc.contributor.author Leal, Mariana Ferreira [UNIFESP]
dc.contributor.author Takeno, Sylvia Satomi [UNIFESP]
dc.contributor.author Assumpcao, Paulo Pimentel de [UNIFESP]
dc.contributor.author Demachki, Samia
dc.contributor.author Smith, Marilia de Arruda Cardoso [UNIFESP]
dc.contributor.author Burbano, Rommel Rodríguez [UNIFESP]
dc.date.accessioned 2018-06-15T13:50:14Z
dc.date.available 2018-06-15T13:50:14Z
dc.date.issued 2005-11-01
dc.identifier http://ar.iiarjournals.org/content/25/6B/4069.abstract
dc.identifier.citation Anticancer Research. Athens: Int Inst Anticancer Research, v. 25, n. 6B, p. 4069-4074, 2005.
dc.identifier.issn 0250-7005
dc.identifier.uri http://repositorio.unifesp.br/11600/42592
dc.description.abstract Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Para has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease. Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas. Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Lauren. No, correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type. Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-WC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process. en
dc.format.extent 4069-4074
dc.language.iso eng
dc.publisher Int Inst Anticancer Research
dc.relation.ispartof Anticancer Research
dc.rights Acesso aberto
dc.subject fluorescence in situ hybridization en
dc.subject chromosome 8 aneuploidy en
dc.subject C-MYC amplification en
dc.subject gastric adenocarcinoma en
dc.title Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma en
dc.type Artigo
dc.contributor.institution Fed Univ Para
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Fed Univ Para, Ctr Ciencias Biol, Dept Biol, Lab Citogenet Humana & Genet Toxicol, BR-66075900 Belem, Para, Brazil
dc.description.affiliation Univ Fed Sao Paulo, Dept Morphol, Discipline Genet, Sao Paulo, SP, Brazil
dc.description.affiliation Fed Univ Para, Joao Barros Barreto Univ Hosp, Dept Pathol, Belem, Para, Brazil
dc.description.affiliation Fed Univ Para, Joao Barros Barreto Univ Hosp, Surg Serv, Belem, Para, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Dept Morphol, Discipline Genet, Sao Paulo, SP, Brazil
dc.description.source Web of Science
dc.identifier.wos WOS:000233278300042



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