Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma

Aneuploidy of chromosome 8 and C-MYC amplification in individuals from northern Brazil with gastric adenocarcinoma

Author Calcagno, Danielle Queiroz Autor UNIFESP Google Scholar
Leal, Mariana Ferreira Autor UNIFESP Google Scholar
Takeno, Sylvia Satomi Autor UNIFESP Google Scholar
Assumpcao, Paulo Pimentel de Autor UNIFESP Google Scholar
Demachki, Samia Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Burbano, Rommel Rodríguez Autor UNIFESP Google Scholar
Institution Fed Univ Para
Universidade Federal de São Paulo (UNIFESP)
Abstract Background: Gastric cancer is the third most frequent type of neoplasia. In northern Brazil, the State of Para has a high incidence of this type of neoplasia. Limited data are available so far on the genetic events involved in this disease. Materials and Methods: Dual-color fluorescence in situ hybridization (FISH) for the C-MYC gene and chromosome 8 centromere was performed in 11 gastric adenocarcinomas. Results: All cases showed aneuploidy of chromosome 8 and C-MYC amplification, in both the diffuse and the intestinal histopathological types of Lauren. No, correlation was found between polysomy 8 and the histopathological characteristics of the tumors. C-MYC amplification, like homogeneously-stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Translocation of C-MYC was observed only in the diffuse-type. Conclusion: Chromosome 8 can be used as a marker in the diagnosis of gastric adenocarcinoma. The C-WC oncogene requires further studies in order to verify if it is, when amplified, an etiological cause of transformation or a consequence of the proliferation process.
Keywords fluorescence in situ hybridization
chromosome 8 aneuploidy
C-MYC amplification
gastric adenocarcinoma
Language English
Date 2005-11-01
Published in Anticancer Research. Athens: Int Inst Anticancer Research, v. 25, n. 6B, p. 4069-4074, 2005.
ISSN 0250-7005 (Sherpa/Romeo, impact factor)
Publisher Int Inst Anticancer Research
Extent 4069-4074
Origin http://ar.iiarjournals.org/content/25/6B/4069.abstract
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000233278300042
URI http://repositorio.unifesp.br/11600/42592

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