ATP REDUCES BLOOD-LOSS PRODUCED BY HEPARIN IN CARDIOPULMONARY BYPASS OPERATIONS

ATP REDUCES BLOOD-LOSS PRODUCED BY HEPARIN IN CARDIOPULMONARY BYPASS OPERATIONS

Author Garcia Junior, Herminio Vega Autor UNIFESP Google Scholar
Buffolo, Enio Autor UNIFESP Google Scholar
Nader, Helena Bonciani Autor UNIFESP Google Scholar
Dietrich, Carl Peter Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract It was previously shown that topical application of heparin produces enhanced bleeding from small vessels and capillaries. Adenosine triphosphate at low concentrations is able to dislodge heparin bound to a receptor, counteracting its antihemostatic activity. These results led us to measure the amounts of heparin remaining in the blood after protamine neutralization of the patients subjected to cardiopulmonary bypass operation and to test the topical application of the nucleotide. Adenosine triphosphate at a concentration of 10(-4) mol/L significantly reduces the blood volume (p < 0.005) oozed from the thoracic cavity of the patients (mean, when compared with controls (mean, 564 +/- 288 mL). Adenosine triphosphate at 5 x 10(-5) mol/L reduces the blood loss to a mean of 370 +/- 155 mt in the patients tested (p < 0.08). About 10% of heparin of low molecular weight (less than or equal to 6.0 Kda), which is also found in the oozed blood, is not neutralized by protamine. We suggest that the excessive blood loss of the patients is probably produced by low molecular weight heparins in the commercial preparations that are not neutralized by protamine.
Language English
Date 1994-04-01
Published in Annals Of Thoracic Surgery. New York: Elsevier Science Inc, v. 57, n. 4, p. 956-959, 1994.
ISSN 0003-4975 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent 956-959
Origin http://dx.doi.org/10.1016/0003-4975(94)90213-5
Access rights Closed access
Type Article
Web of Science ID WOS:A1994NF98200035
URI http://repositorio.unifesp.br/11600/42582

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