Action of plant proteinase inhibitors on enzymes of physiopathological importance

Action of plant proteinase inhibitors on enzymes of physiopathological importance

Author Oliva, Maria Luiza Vilela Autor UNIFESP Google Scholar
Sampaio, Misako Uemura Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.
Keywords Bowman-Birk
chymotrypsin
Kunitz inhibitors
plasma kallikrein
primary structure
trypsin
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Fundo de Auxilio aos Docentes e Alunos/Fundacao de Apoio a UNIFESP (FADA/FAP)
Date 2009-09-01
Published in Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 615-621, 2009.
ISSN 0001-3765 (Sherpa/Romeo, impact factor)
Publisher Acad Brasileira De Ciencias
Extent 615-621
Origin http://dx.doi.org/10.1590/S0001-37652009000300023
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000269462300023
SciELO ID S0001-37652009000300023 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42527

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