B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties

B-1 cell: the precursor of a novel mononuclear phagocyte with immuno-regulatory properties

Author Lopes, Jose Daniel Autor UNIFESP Google Scholar
Mariano, Mario Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Characterization of the origin, properties, functions and fate of cells is a fundamental task for the understanding of physiological and pathological phenomena. Despite the bulk of knowledge concerning the diverse characteristics of mammalian cells, some of them, such as B-1 cells, are still poorly understood. Here we report the results obtained in our laboratory on these cells in the last 10 years. After showing that B-1 cells could be cultured and amplified in vitro, a series of experiments were performed with these cells. They showed that B1 cells reside mostly in the peritoneal and pleural cavities, migrate to distant inflammatory foci, coalesce to form giant cells and participate in granuloma formation, both in vitro and in vivo. They are also able to present antigens to immunologically responsive cells and are endowed with regulatory properties. Further, we have also shown that these cells facilitate different types of infection as well as tumor growth and spreading. These data are presently reviewed pointing to a pivotal role that these cells may play in innate and acquired immunity.
Keywords B-1 cells
IL-10
inflammation
infection
neoplasia
BALB/Xid mice
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number FAPESP: 07/51501-9
FAPESP: 04/08506-1
Date 2009-09-01
Published in Anais Da Academia Brasileira De Ciencias. Rio Janeiro: Acad Brasileira De Ciencias, v. 81, n. 3, p. 489-496, 2009.
ISSN 0001-3765 (Sherpa/Romeo, impact factor)
Publisher Acad Brasileira De Ciencias
Extent 489-496
Origin http://dx.doi.org/10.1590/S0001-37652009000300013
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000269462300013
SciELO ID S0001-37652009000300013 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/42526

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