Determinants of the exercise endurance capacity in patients with chronic obstructive pulmonary disease - The power-duration relationship

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dc.contributor.author Neder, Jose Alberto [UNIFESP]
dc.contributor.author Jones, Paul W.
dc.contributor.author Nery, Luiz Eduardo [UNIFESP]
dc.contributor.author Whipp, Brian J.
dc.date.accessioned 2018-06-15T13:20:16Z
dc.date.available 2018-06-15T13:20:16Z
dc.date.issued 2000-08-01
dc.identifier http://dx.doi.org/10.1164/ajrccm.162.2.9907122
dc.identifier.citation American Journal Of Respiratory And Critical Care Medicine. New York: Amer Lung Assoc, v. 162, n. 2, p. 497-504, 2000.
dc.identifier.issn 1073-449X
dc.identifier.uri http://repositorio.unifesp.br/11600/42379
dc.description.abstract To characterize the determinants of the power-duration (W over dot -t) relationship in patients with chronic obstructive pulmonary disease (COPD), we evaluated 8 nonhypoxemic patients (FEV1 = 1.27 +/- 0.26 L) and 10 healthy controls. After an initial maximum-incremental exercise test on cycle ergometer (peak), the subjects underwent four high-intensity constant-load tests to the limit of tolerance (t), each on different days. The W over dot -t relationship was found to be hyperbolic in both groups. Absolute values of both the critical power asymptote (theta(F)) and the curvature constant (W') were lower in patients than in control subjects. However, when expressed as percentage of peak work rate theta(F) was significantly higher in patients compared with control subjects (81.8 +/- 3.3% versus 67.5 +/- 3.7%, respectively, p < 0.01). There were severe reductions in t in the patients that were consistently associated with higher breathlessness scores and V over dot (E)/MVV ratios. Interestingly, all patients were able to sustain exercise at BF for 20 min despite near-maximum physiological and subjective stresses. We conclude that the reductions of both parameters of the hyperbolic W over dot -t relationship (theta(F) and W') in patients with COPD were due to the ventilatory constraints and their sensory consequences. Importantly, theta(F) separated a sustainable from a nonsustainable exercise-intensity domain: this parameter consistently occurred closer to peak work rate in patients than the healthy control subjects. en
dc.format.extent 497-504
dc.language.iso eng
dc.publisher Amer Lung Assoc
dc.relation.ispartof American Journal Of Respiratory And Critical Care Medicine
dc.rights Acesso restrito
dc.title Determinants of the exercise endurance capacity in patients with chronic obstructive pulmonary disease - The power-duration relationship en
dc.type Artigo
dc.contributor.institution Univ London
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Univ London, St George Hosp, Sch Med, Dept Physiol, London, England
dc.description.affiliation Univ London, St George Hosp, Sch Med, Dept Med Physiol, London, England
dc.description.affiliation Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Div Resp, Sao Paulo, Brazil
dc.description.affiliationUnifesp Univ Fed Sao Paulo, Escola Paulista Med, Dept Med, Div Resp, Sao Paulo, Brazil
dc.identifier.doi 10.1164/ajrccm.162.2.9907122
dc.description.source Web of Science
dc.identifier.wos WOS:000088829200028



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