REGRESSION OF LEFT-VENTRICULAR HYPERTROPHY IN THE SHORT-TERM TREATMENT OF HYPERTENSION WITH ISRADIPINE

REGRESSION OF LEFT-VENTRICULAR HYPERTROPHY IN THE SHORT-TERM TREATMENT OF HYPERTENSION WITH ISRADIPINE

Author Saragoça. Manoel Antonio da Silva Autor UNIFESP Google Scholar
Portela, Jorge E. Autor UNIFESP Google Scholar
Abreu, Patricia Autor UNIFESP Google Scholar
Plavnik, Frida Liane Autor UNIFESP Google Scholar
Vanneta, Adalia Autor UNIFESP Google Scholar
Ajzen, Horacio Autor UNIFESP Google Scholar
Ramos, Oswaldo Luiz Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract This was a study of the effectiveness of isradipine, a calcium antagonist of the dihydropyridine group, in reversing left ventricular hypertrophy (LVH) in patients with mild-to-moderate hypertension. Mean arterial pressure was effectively reduced at 90 days of treatment (from 129.5 +/- 2.0 to 111.5 +/- 2.8 mm Hg; P < .001). The electrocardiographic Romhilt-Estes score for LVH showed early reduction at 45 days of treatment (from 7.1 +/- 0.6 to 5.1 +/- 0.4 points; P < .001), and further diminutions were observed at 90 days of treatment (3.8 +/- 0.4 points; P < .01). The echocardiographically determined left ventricular mass indices confirmed these findings (from 175.0 +/- 8.9 to 141.7 +/- 5.5 and to 124.8 +/- 4.2 g/m2; P < .001) for 45 and 90 days, respectively. The results indicate that isradipine is effective in reducing left ventricular mass and that these reductions are observed early in the course of treatment.
Keywords LEFT VENTRICULAR HYPERTROPHY
REGRESSION
CALCIUM ANTAGONISTS
ISRADIPINE
HYPERTENSION
Language English
Date 1991-02-01
Published in American Journal Of Hypertension. New York: Elsevier Science Inc, v. 4, n. 2, p. S188-S190, 1991.
ISSN 0895-7061 (Sherpa/Romeo, impact factor)
Publisher Elsevier B.V.
Extent S188-S190
Origin http://ajh.oxfordjournals.org/content/4/2_Pt_2/188S.abstract
Access rights Closed access
Type Article
Web of Science ID WOS:A1991EZ45200027
URI http://repositorio.unifesp.br/11600/42305

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