NAILFOLD CAPILLAROSCOPY ABNORMALITIES CORRELATE WITH CUTANEOUS AND VISCERAL INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS

NAILFOLD CAPILLAROSCOPY ABNORMALITIES CORRELATE WITH CUTANEOUS AND VISCERAL INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS

Author Sato, Lucy Tiemi Autor UNIFESP Google Scholar
Kayser, Cristiane Autor UNIFESP Google Scholar
Andrade, Luiz Eduardo Coelho Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Objective: The aim of this study was to correlate quantitative and semiquantitative nailfold capillaroscopy (NFC) parameters with the extent of cutaneous and visceral involvement in systemic sclerosis (SSc) patients.Methods: The presence of clinical and serological alterations was evaluated retrospectively and correlated with NFC findings (number of capillary loops/mm, vascular deletion score and number of enlarged and giant capillary loops). For evaluation of disease extension five manifestations were analyzed: finger pad lesions, skin involvement, esophageal involvement, interstitial lung disease, and pulmonary hypertension.Results: There were 105 NFC examinations in 92 patients, 13 of whom were evaluated at two different time points. Patients with diffuse cutaneous SSc had a higher vascular deletion score than patients with limited cutaneous SSc, sine scleroderma SSc, and overlap syndrome (1.67 +/- 0.91 vs 0.99 +/- 0.82; p=0.0005). Modified Rodnan's skin score correlated positively with capillary deletion, evaluated by the vascular deletion score and the number of capillary loops/mm (p<0.001 and p=0.012; respectively). Patients with three or more involved tracts presented lower number of capillary loops/mm (8.00 +/- 1.69 vs 9.23 +/- 1.31 capillary loops/mm; p=0.025) and a higher vascular deletion score (1.41 +/- 0.95 vs 0.73 +/- 0.76; p=0.027) when compared to patients with less than three affected tracts. Vascular deletion score was higher in patients with anti-Scl-70 antibodies that in patients without anti-Scl-70 antibodies (p=0.02).Conclusions: NFC abnormalities correlated positively with the diffuse form of SSc, the degree of cutaneous involvement, the number of affected tracts, and the presence of anti-Scl-70 antibodies.
Keywords Microcirculation
Nailfold capillaroscopy
Raynaud's phenomenon
Systemic sclerosis
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Brazilian Society of Rheumatology
Date 2009-04-01
Published in Acta Reumatologica Portuguesa. Alges: Medfarma-edicoes Medicas, Lda, v. 34, n. 2, p. 219-227, 2009.
ISSN 0303-464X (Sherpa/Romeo, impact factor)
Publisher Medfarma-edicoes Medicas, Lda
Extent 219-227
Origin http://www.actareumatologica.pt/article_download.php?id=417
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000266220000008
URI http://repositorio.unifesp.br/11600/42085

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