Impact of highly active antiretroviral therapy in the treatment of HIV-infected patients with systemic non-Hodgkin's lymphoma

Impact of highly active antiretroviral therapy in the treatment of HIV-infected patients with systemic non-Hodgkin's lymphoma

Author Baiocchi, Otavio Carvalho Guimarães Autor UNIFESP Google Scholar
Colleoni, Gisele Wally Braga Autor UNIFESP Google Scholar
Navajas, Eduardo Vitor Autor UNIFESP Google Scholar
Duarte, Luiz Cláudio de Carvalho Autor UNIFESP Google Scholar
Alves, Antonio Correa Autor UNIFESP Google Scholar
Andrade, Ana Lúcia Sampaio Sgambatti de Google Scholar
Kerbauy, José Autor UNIFESP Google Scholar
Oliveira, José Salvador Rodrigues de Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás (UFG)
Abstract Twenty cases of systemic non-Hodgkin's lymphoma (NHL) in HIV-infected patients were reviewed over a 10-year-period, divided into Group A, including 13 NHL cases treated before the highly active antiretroviral therapy (HAART) era, and Group B, including 7 patients who received HAART. A Kaplan-Meier survival curve was performed and log-rank was applied to assess statistical differences between the groups. In group A, the median CD4 count was 36 cells/mm(3). No complete remission was found. In group B, the median CD4 count was 137 cells/mm(3). Four patients (57.0%) are still alive and in complete remission. Group A had a median survival of 5 months and group B 31 months (p = 0.0032). Our results are in agreement with recent reports in that a higher CD4 count and better immune status achieved with HAART is predictive of a better outcome. We found that HAART in combination with chemotherapy improves overall survival of NHL patients without increasing adverse effects.
Language English
Date 2002-04-01
Published in Acta Oncologica. Oslo: Taylor & Francis As, v. 41, n. 2, p. 192-196, 2002.
ISSN 0284-186X (Sherpa/Romeo, impact factor)
Publisher Taylor & Francis As
Extent 192-196
Origin http://dx.doi.org/10.1080/028418602753669599
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000175951000014
URI http://repositorio.unifesp.br/11600/42008

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