Atypical glandular cells of undetermined significance - Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions

Atypical glandular cells of undetermined significance - Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions

Autor Ferraz, Maria da Gloria Mattosinho de Castro Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Stavale, Joao Norberto Autor UNIFESP Google Scholar
Nicolau, Sergio Mancini Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmond Chada Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVE: To verify the cytologic predictive value of a diagnosis of atypical glandular cells of undetermined significance (AGUS) in high grade squamous intraepithelial lesions (HSIL) cases.STUDY DESIGN: In a retrospective study, 98 cases of HSIL were reviewed. All patients were referred for colposcopy and directed biopsy to confirm the cytologic diagnoses. Loop excision of the transformation zone was performed to treat clinical lesions. Sensitivity, specificity, positive and negative predictive value were evaluated. Kappa statistics and logistic regression analysis were used to evaluate the findings statistically.RESULTS: By logistic regression analysis, we found that the chance of finding squamous intraepithelial lesions involving glands in AGUS smears was 5.32 times higher than in those with no AGUS. It was 5.74 times higher in cervical intraepithelial neoplasia (CIN) 3 lesions than in CIN 2.CONCLUSION: The cytologic predictive value for HSIL involving glands is statistically significant when specific and objective criteria are used for the AGUS diagnosis.
Assunto cervical cancer
cervix neoplasms
cervi-
Idioma Inglês
Data 2003-03-01
Publicado em Acta Cytologica. St Louis: Sci Printers & Publ Inc, v. 47, n. 2, p. 154-158, 2003.
ISSN 0001-5547 (Sherpa/Romeo, fator de impacto)
Editor Sci Printers & Publ Inc
Extensão 154-158
Fonte http://dx.doi.org/10.1159/000326496
Direito de acesso Acesso restrito
Tipo Artigo
Web of Science WOS:000181625300008
URI http://repositorio.unifesp.br/11600/41988

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