Atypical glandular cells of undetermined significance - Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions

Atypical glandular cells of undetermined significance - Cytologic predictive value for glandular involvement in high grade squamous intraepithelial lesions

Author Ferraz, Maria da Gloria Mattosinho de Castro Autor UNIFESP Google Scholar
Focchi, José Autor UNIFESP Google Scholar
Stavale, Joao Norberto Autor UNIFESP Google Scholar
Nicolau, Sergio Mancini Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmond Chada Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: To verify the cytologic predictive value of a diagnosis of atypical glandular cells of undetermined significance (AGUS) in high grade squamous intraepithelial lesions (HSIL) cases.STUDY DESIGN: In a retrospective study, 98 cases of HSIL were reviewed. All patients were referred for colposcopy and directed biopsy to confirm the cytologic diagnoses. Loop excision of the transformation zone was performed to treat clinical lesions. Sensitivity, specificity, positive and negative predictive value were evaluated. Kappa statistics and logistic regression analysis were used to evaluate the findings statistically.RESULTS: By logistic regression analysis, we found that the chance of finding squamous intraepithelial lesions involving glands in AGUS smears was 5.32 times higher than in those with no AGUS. It was 5.74 times higher in cervical intraepithelial neoplasia (CIN) 3 lesions than in CIN 2.CONCLUSION: The cytologic predictive value for HSIL involving glands is statistically significant when specific and objective criteria are used for the AGUS diagnosis.
Keywords cervical cancer
cervix neoplasms
cervi-
Language English
Date 2003-03-01
Published in Acta Cytologica. St Louis: Sci Printers & Publ Inc, v. 47, n. 2, p. 154-158, 2003.
ISSN 0001-5547 (Sherpa/Romeo, impact factor)
Publisher Sci Printers & Publ Inc
Extent 154-158
Origin http://dx.doi.org/10.1159/000326496
Access rights Closed access
Type Article
Web of Science ID WOS:000181625300008
URI http://repositorio.unifesp.br/11600/41988

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