Apoptotic effects of inositol hexaphosphate on biomarker Itpr3 in induced colon rat carcinogenesis

Apoptotic effects of inositol hexaphosphate on biomarker Itpr3 in induced colon rat carcinogenesis

Alternative title Efeito de apoptose do inositol hexafosfato no marcador biológico Itpr3 em carcinogênese induzida de colo em ratos
Author Marks, Guido Autor UNIFESP Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Ynouye, Celso Massaschi Google Scholar
Pontes, Elenir Rose Jardim Cury Google Scholar
Takita, Luiz Carlos Autor UNIFESP Google Scholar
Amaral, Eva Glória Abrão Siufi do Autor UNIFESP Google Scholar
Teruya, Roberto Autor UNIFESP Google Scholar
Paes, Manoel Catarino Google Scholar
Brasileiro, José Lacerda Autor UNIFESP Google Scholar
Aydos, Ricardo Dutra Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Mato Grosso do Sul (UFMS)
Abstract Purpose: To study the effect of the modulation of inositol hexaphosphate (IP6) in the biological immunohistochemistry expression of cellular signaling marker apoptosis, in model of carcinogenesis of colon induced by azoxymethane (AOM). Methods: Wistar rats (N= 112) distributed in 4 groups (n=28): Control; B, AOM (5 mg kg(-1), 2x, to break week 3); C, IP6 (in water 1 %, six weeks); D, IP6+AOM. Weekly euthanasia (n=7), from week three. Immunohistochemistry of ascendant colon with biological marker inositol 1,4,5 triphosphate receptor type III (Itpr3). Quantification of the immune-expression with use of computer-assisted image processing. Analysis statistics of the means between groups, weeks in groups, groups in weeks, and established significance when p <= 0.05. Results: One proved significant difference between groups in the expression of Itpr3, p < 0.0001;with Itpr3 reduction of BxD group, p < 0.001. Conclusion: Inositol hexaphosphate promotes modulation of biological markers with reduction of Itpr3 in carcinogenesis of colon.
Keywords apoptosis
azoxymethane
cancer
colon
inositol 1,4,5 trisphosphate receptors
computer-assisted image processing
phytic acid
rats
Language English
Sponsor Federal University of Mato Grosso of South
Date 2008-03-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 157-164, 2008.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 157-164
Origin http://dx.doi.org/10.1590/S0102-86502008000200008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258661800008
SciELO ID S0102-86502008000200008 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/41977

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