Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats

Effect of anti-inflammatory agents on the integration of autogenous bone graft and bovine bone devitalized matrix in rats

Alternative title Efeito de antiinflamatórios na integração de enxerto ósseo autógeno e de matriz óssea bovina desvitalizada em ratos
Author Silva, Roberto Antoniolli da Autor UNIFESP Google Scholar
Fagundes, Djalma José Autor UNIFESP Google Scholar
Silva, Andreia Conceicao Milan Brochado Antoniolli Google Scholar
Sisti, Karin Ellen Google Scholar
Carvalho, Themis Maria Milan Brochado de Google Scholar
Silva, Daniel Nunes e Google Scholar
Institution Universidade Federal de Mato Grosso do Sul (UFMS)
Universidade Federal de São Paulo (UNIFESP)
Abstract Purpose: To study the repair of bone defect filled with autograft or bovine bone devitalized matrix in rats under anti-inflammatory action. Methods: Two hundred and forty Wistar rats were distributed to two groups of 120 animals each. A 2mm-diameter defect was created in the femoral diaphysis. Animals of Group I had the bone defect filled with autograft and those of Group II, with bovine bone devitalized matrix. Animals of each group were redistributed to four subgroups according to the intramuscular administration of anti-inflammatory drug or saline solution: A - diclofenac sodium; B - dexamethasone; C - meloxicam; D - saline solution. Evaluation periods were 7, 14 and 30 days. Histological evaluation consisted of quantifying the inflammatory process, the bone neoformation, the collagen formation and the presence of macrophages. Results: Animals of Group I did not show significant difference considering inflammatory reaction. Significant and progressive increase of bone neoformation was observed in both groups. The animals that received meloxicam and autograft showed less collagen formation at 14 and 30 days. The number of macrophages was higher in Group II than in Group I. The animals treated with dexamethasone and saline Solution did not show statistically significant difference. Conclusions: Diclofenac sodium and meloxicam delayed bone graft repair and dexamethasone did not interfere in it.
Keywords bone transplantation
anti-inflammatory agents
rats, wistar
Language English
Date 2008-03-01
Published in Acta Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 23, n. 2, p. 140-148, 2008.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Acta Cirurgica Brasileira
Extent 140-148
Origin http://dx.doi.org/10.1590/S0102-86502008000200006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258661800006
SciELO ID S0102-86502008000200006 (statistics in SciELO)
URI http://repositorio.unifesp.br/11600/41976

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