Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic

Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic

Author Mimura, Maria Angela Martins Autor UNIFESP Google Scholar
Borra, Ricardo Carneiro Google Scholar
Hirata, Cleonice Hitomi Watashi Autor UNIFESP Google Scholar
Penido, Norma de Oliveira Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract Background: There are indications that Th1 polarization of immune response plays an important role in the pathogenesis of recurrent aphthous stomatitis (RAS), and that the use of probiotics can stimulate immune regulatory activity, influencing the course of the disease. The aim of this study was to characterize the initial immune profile of RAS patients and evaluate clinical and serological response following a challenge with symbiotic treatment containing fructooligosaccharide, Lactobacillus, and Bifidobacterium. Methods: The immune responses of the 45 patients with RAS, submitted to symbiotic or placebo for 120 days, in relation to 30 RAS-free controls, were evaluated over a period of 6 months. Peripheral blood was collected from all patients at 0 (T0), 120 (T4), and 180 days (T6) after the start of treatment and Th1 (IL12-p70,IFN-c), Th2 (IL-4), Treg (IL-10), Th17 (IL-17A), inflammatory (TNF-a, IL-6)-associated cytokines, and clinical parameters were quantified. Results: At T0, significant differences were found in the serological levels of the IFN-c, IL-4, and IL-6 cytokines of the RAS patients in comparison with the controls. It was observed that the cytokine profile of the RAS group was comprised of 2 distinct clusters: a pure Th2 and a Mixed (Th1/Th2) subtype and that symbiotic treatment induced an improvement in pain and an increase in IFN-c levels, producing a reduction in Th2 response. Conclusions: In RAS, symbiotic treatment based on a fructooligosaccharide, Lactobacillus, and Bifidobacterium composition produced an alteration in the Th2 serological immune profile in the direction of Th1 and improved pain symptomatology.
Keywords Cytokines
Immunology
Recurrent aphthous stomatitis
Treatment
Language English
Sponsor Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Date 2017-10-04
Published in Mimura Maria Angela Martins, Borra Ricardo Carneiro, Hirata Cleonice Hitomi Watashi, Penido Norma de Oliveira. Immune response of patients with recurrent aphthous stomatitis challenged with a symbiotic. J Oral Pathol Med. 2017;46:821–828. https://doi.org/10.1111/jop.12621
ISSN 1600-0714 (Sherpa/Romeo, impact factor)
0904-2512 (Sherpa/Romeo, impact factor)
Publisher Wiley
Origin https://onlinelibrary.wiley.com/doi/abs/10.1111/jop.12621
Access rights Closed access
Type Article
Web of Science ID WOS:000412303500025
URI http://repositorio.unifesp.br/11600/41779

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