TNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

TNF-α and IL-6 immunohistochemistry in rat renal tissue experimentaly infected with Leptospira interrogans serovar Canicola

Autor Marinho, Márcia Google Scholar
Monteiro, Cristina Maria Rodrigues Google Scholar
Peiró, Jr Google Scholar
Machado, Gf Google Scholar
Oliveira-Júnior, Itamar Souza Autor UNIFESP Google Scholar
Instituição Universidade Estadual Paulista (UNESP)
Universidade Federal de São Paulo (UNIFESP)
Resumo Leptospirosis is a public health problem worldwide and its etiology remains unclear. Its pathogenesis involves a complex interaction between host and infecting microorganism. The inflammatory reaction that controls the infection process also underscores many pathophysiological events occurring in leptospirosis. We investigated the presence of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in renal tissues by immunohistochemical and histopathological examination in animals experimentally inoculated with Leptospira serovar Canicola. All the tests were carried out 2, 7, 14, 21 or 28 days after inoculation. Although TNF-α and IL-6 had been detected in tissues throughout the observation period, these cytokines appeared more intensely during the initial phase of infection. Therefore, both TNF-α and IL-6 were associated with the immunopathogenesis of leptospirosis. This profile suggests a high immunocellular response throughout the early infection stages followed by subsequent humoral response.
Palavra-chave leptospirosis
immunohistochemistry
IL-6
TNF-α
mice
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Data de publicação 2008-01-01
Publicado em Journal of Venomous Animals and Toxins including Tropical Diseases. Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP, v. 14, n. 3, p. 533-540, 2008.
ISSN 1678-9199 (Sherpa/Romeo, fator de impacto)
Publicador Centro de Estudos de Venenos e Animais Peçonhentos - CEVAP, Universidade Estadual Paulista - UNESP
Extensão 533-540
Fonte http://dx.doi.org/10.1590/S1678-91992008000300012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000259279500012
SciELO S1678-91992008000300012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4149

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