Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?

Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?

Author Lobo, Vera Lúcia Rodrigues Autor UNIFESP Google Scholar
Soares Júnior, José Maria Autor UNIFESP Google Scholar
Simões, Manuel de Jesus Autor UNIFESP Google Scholar
Simões, Ricardo dos Santos Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Abstract OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen's effects on rat peritoneal endometrial implants.
Keywords Experimental endometriosis
Peritoneal implants
Ovariectomized rats
Language English
Date 2008-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 63, n. 4, p. 525-530, 2008.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 525-530
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000258504600019
SciELO ID S1807-59322008000400019 (statistics in SciELO)

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