Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?

Does gestrinone antagonize the effects of estrogen on endometrial implants upon the peritoneum of rats?

Autor Lobo, Vera Lúcia Rodrigues Autor UNIFESP Google Scholar
Soares Júnior, José Maria Autor UNIFESP Google Scholar
Simões, Manuel de Jesus Autor UNIFESP Google Scholar
Simões, Ricardo dos Santos Autor UNIFESP Google Scholar
Lima, Geraldo Rodrigues de Autor UNIFESP Google Scholar
Baracat, Edmund Chada Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade de São Paulo (USP)
Resumo OBJECTIVE: To evaluate the effects of estrogen treatment in combination with gestrinone on an experimental rat model of endometriosis. METHODS: Uterine transplants were attached to the peritoneum of female Wistar rats via a surgical autotransplantation technique. The implanted area was measured during the proestrus phase and after hormonal treatment. We performed morphometric analysis and examined the macroscopic and morphometric alterations of endometrial implants after hormonal treatment in ovariectomized rats. RESULTS: The high dose of estrogen caused macroscopic increases in the endometrial implant group compared with other groups, which were similar to increases in the proestrus phase. The low dose showed morphometric development of implants, such as an increase in number of endometrial glands, leukocyte infiltration and mitosis. Gestrinone antagonized both doses of estrogen. CONCLUSION: Our findings suggest that gestrinone antagonizes estrogen's effects on rat peritoneal endometrial implants.
Palavra-chave Experimental endometriosis
Peritoneal implants
Ovariectomized rats
Gestrinone
Estrogen
Idioma Inglês
Data de publicação 2008-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 63, n. 4, p. 525-530, 2008.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 525-530
Fonte http://dx.doi.org/10.1590/S1807-59322008000400019
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258504600019
SciELO S1807-59322008000400019 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4143

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