The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock

The impact of duration of organ dysfunction on the outcome of patients with severe sepsis and septic shock

Autor Freitas, Flavio Geraldo Rezende Autor UNIFESP Google Scholar
Salomão, Reinaldo Autor UNIFESP Google Scholar
Tereran, Nathalia Autor UNIFESP Google Scholar
Mazza, Bruno Franco Autor UNIFESP Google Scholar
Assunção, Murillo Autor UNIFESP Google Scholar
Jackiu, Mirian Autor UNIFESP Google Scholar
Fernandes, Haggeas Autor UNIFESP Google Scholar
Machado, Flávia Ribeiro Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo OBJECTIVES: This study aimed to assess the impact of the duration of organ dysfunction on the outcome of patients with severe sepsis or septic shock. METHODS: Clinical data were collected from hospital charts of patients with severe sepsis and septic shock admitted to a mixed intensive care unit from November 2003 to February 2004. The duration of organ dysfunction prior to diagnosis was correlated with mortality. Results were considered significant if p<0.05. RESULTS: Fifty-six patients were enrolled. Mean age was 55.6 ± 20.7 years, mean APACHE II score was 20.6 ± 6.9, and mean SOFA score was 7.9 ± 3.7. Thirty-six patients (64.3%) had septic shock. The mean duration of organ dysfunction was 1.9 ± 1.9 days. Within the univariate analysis, the variables correlated with hospital mortality were: age (p=0.015), APACHE II (p=0.008), onset outside the intensive care unit (p=0.05), blood glucose control (p=0.05) and duration of organ dysfunction (p=0.0004). In the multivariate analysis, only a duration of organ dysfunction persisting longer than 48 hours correlated with mortality (p=0.004, OR: 8.73 (2.37-32.14)), whereas the APACHE II score remained only a slightly significant factor (p=0.049, OR: 1.11 (1.00-1.23)). Patients who received therapeutic interventions within the first 48 hours after the onset of organ dysfunction exhibited lower mortality (32.1% vs. 82.1%, p=0.0001). CONCLUSIONS: These findings suggest that the diagnosis of organ dysfunction is not being made in a timely manner. The time elapsed between the onset of organ dysfunction and initiation of therapeutic intervention can be quite long, and this represents an important determinant of survival in cases of severe sepsis and septic shock.
Palavra-chave Sepsis diagnosis
Sepsis management
Surviving Sepsis Campaign
Intensive care
Infection
Idioma Inglês
Data de publicação 2008-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 63, n. 4, p. 483-488, 2008.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 483-488
Fonte http://dx.doi.org/10.1590/S1807-59322008000400012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000258504600012
SciELO S1807-59322008000400012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/4129

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